The Open Respiratory Medicine Journal

ISSN: 1874-3064 ― Volume 13, 2019

24-Hour Hypoxia and Pulmonary Hypertension in Patients with Idiopathic Pulmonary Fibrosis

Marcelo P. Rodrigues1, *, Carolina M. Vissoci2, Samuel P. Rosa3, Sandra B.C. Negreiros1
1 Department of Pulmonology, School of Medicine, Universidade de Brasília (UnB), Brasília, DF, Brazil
2 Student of Medicine. School of Medicine, UnB, Brasília, DF, Brazil
3 Department of Cardiology, Hospital de Base, Brasília, DF, Brazil



The quantification of hypoxia based on resting partial pressure of arterial oxygen (PaO2) may underestimate hypoxia related to activities of daily living or sleep and thus not accurately reflect pulmonary hypertension (PH). The aim of the present study was to investigate the association of resting PaO2 with percent time of SpO2 below 90% (T90) and 88% (T88) in 24 hours. We also evaluated the capacity of hypoxia measures to predict PH in patients with idiopathic pulmonary fibrosis (IPF).


This cross-sectional study included 27 patients with IPF presenting PaO2 ≥ 55 mmHg and not receiving home oxygen therapy. All were submitted to blood gas measurement, 24-h oximetry, and transthoracic Doppler echocardiography to estimate systolic pulmonary artery pressure (SPAP). Patients were divided into three groups according to resting PaO2: 55-55.9 mmHg (A); 60-60.9 mmHg (B); ≥ 70 mmHg (C). PH was defined as “likely” if SPAP > 50 mmHg, and as possible for SPAP between 37 and 50 mmHg.


T90 and T88 in Groups A, B, and C were as follows: 59.9±29% and 44.1±34%; 49.3±34% and 29.9±31%; 17.1±25% and 8.8±18% respectively, with significant differences between the groups for both T90 (p ≤ 0.01) and T88 (p = 0.02). PaO2 was inversely correlated with T90 (r = -0.398; p = 0.04) and T88 (r = -0.351; p = 0.07). Hypoxia variables did not correlate with SPAP, and were not able to predict PH.


Percent time of SpO2 below 90% and 88% in 24 hours revealed periods of severe hypoxia even in patients with borderline-normal resting PaO2. However, none of the present hypoxia variables was capable of predicting PH.

Keywords: Hypertension, Pulmonary, Hypoxia, Idiopathic pulmonary fibrosis, Blood gas monitoring, Transcutaneous.

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 11
First Page: 10
Last Page: 16
Publisher Id: TORMJ-11-10
DOI: 10.2174/1874306401711010010

Article History:

Received Date: 09/12/2016
Revision Received Date: 03/03/2017
Acceptance Date: 03/03/2017
Electronic publication date: 29/05/2017
Collection year: 2017

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© 2017 Rodrigues et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the SQSW 306, B, 603, Setor Sudoeste 70673-432 - Brasília, DF, Brazil, Tel: +55-61-8433-0879; E-mail:


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