REVIEW ARTICLE
The Emerging Role of The Eosinophil and Its Measurement in Chronic Cough
Mahboobeh H. Sadeghi, Alyn H. Morice*
Respiratory Medicine, Castle Hill Hospital, Centre for Cardiovascular and Metabolic Research, Hull York Medical School, Cottingham, UK.
Article Information
Identifiers and Pagination:
Year: 2017Volume: 11
First Page: 17
Last Page: 30
Publisher ID: TORMJ-11-17
DOI: 10.2174/1874306401711010017
Article History:
Received Date: 07/04/2017Revision Received Date: 29/04/2017
Acceptance Date: 08/05/2017
Electronic publication date: 30/06/2017
Collection year: 2017
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Although the aetiology of chronic cough in guidelines is clearly stated as asthma and related syndromes, gastro-oesophageal reflux disease (GORD), and upper airways disease, the inflammatory mechanisms underlying these conditions differ. Recent studies on asthma have increasingly focused on its molecular phenotypes instead of clinical characteristics. Here, we proposed the hypothesis that divides cough into two groups; the eosinophilic and neutrophilic. This division will enhance our ability to recognise the type of airway inflammation which, as a consequence will lead us to more targeted and personalized treatment approaches.
Keywords: Chronic Cough, Eosinophil, Cough variant asthma, Eosinophilic bronchitis, Montelukast, Innate immunity.
