Intraoperative angiography or lymphography with an Indocyanine Green (ICG) fluorescence imaging technique is becoming popular clinical tool. Since 2003, it started to use for Beast Cancer Sentinel Lymph Node Navigation, the applications increased rapidly to other fields such as plastic and reconstruction surgery, brain surgery, Gastroenterological Surgery, and so on. Thus the ICG fluorescence method is a very powerful device for intraoperative navigator and also it’s expected some improvement for the real diagnostic tool. We will explain the principle of ICG fluorescence method and the subjects to be improved.