The Open Sports Sciences Journal

ISSN: ― Volume ,

The Influence of Aquarobic Training Towards Interleukin 12 (IL-12) Plasma Level and Its Correlation with Obesity

Ronny Lesmana1, 3, *, Farras Cahyo Bawono Setiawan1, Siti Baitul Mukaromah4, Hanna Goenawan1, 3, Vita Murniati Tarawan1, 3, Maya Kusumawati2, Unang Supratman3, 5, Iwan Setiawan1, 3
1 Department of Anatomy, Physiology, and Biology of Cell, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;
2 Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia;
3 Physiology Molecular Laboratory, Biological Activity Division, Central Laboratory, Universitas Padjadjaran, Bandung, Indonesia.
4 Laboratory of Sport Science, Sport Science Faculty, Universitas Negeri Semarang, Semarang, Indonesia.
5 Departement of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Bandung, Indonesia.



Interleukin 12 (IL-12) has been of interest during the advancement of insulin obstruction in stout mice. Serum IL-12 levels have not precisely been decided in obese people and neither is its regulation by aquarobic training (recommended sport type for obese people which is less stressor for hefty individual joints).


This research aims to discover the alteration pattern of IL-12 in serum of obese people based on BMI, examine their relationship with obesity-related parameters and how it can be modulated by aquarobic training.


First study wasa cross-sectional study conducted on 34 obese adults ranging from 33 – 57 years old. The study used primary data which were blood samples from adult obese. For reducing the risk for the obese patients, in second study, we recruited 12 healthy volunteers for a 12 week aquarobic training program. Using enzyme-linked immunosorbent assay (ELISA) methods, we observed that serum IL-12 level was altered by different levels of BMI and correlated with other factors like Low Density Lipoprotein level, Cholesterol level and Waist Ratio.


The group with BMI between 27.01 – 29.99, have IL-12 level of 94.102 ± 35.19 pg/mL. Group with BMI 30.00 – 33.99 have 96.068 ± 59.44pg/mL, and those with BMI more than 33.99 have IL-12 level of 114.572 ± 74.22 pg/mL.


Interestingly, it was observed that 12 week aquarobic training can significantly reduce the IL-12 level. Taken together, IL12 level may play an important role in obesity and can be potentially modulated by aquarobic training.

Keywords: Obesity, IL-12, Inflammation, Aquarobic training, Metabolic syndrome, Low density lipoprotein level.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 13
First Page: 34
Last Page: 41
Publisher Id: TOSSJ-13-34
DOI: 10.2174/1875399X02013010034

Article History:

Received Date: 04/12/2019
Revision Received Date: 21/02/2020
Acceptance Date: 24/02/2020
Electronic publication date: 30/06/2020
Collection year: 2020

© 2020 Lesmana et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Universitas padjadjaranpadjadjaran, Biomedical Science , Jalan jatinangor km 21,6 , Bandung, Indonesia, Tel: +62227794585,

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