Molecular Genetics of Human Personality Traits for Psychiatric, Behavioral, and Substance-Related Disorders
Eugene Lin*
, 1, Po See Chen*
, 2, 3
1 Vita Genomics, Inc., 7 Fl., No. 6, Sec. 1, Jung-Shing Road, Wugu Shiang, Taipei, Taiwan
2 Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan
3 National Cheng Kung University Hospital and Dou-Liou Branch, Taiwan
Abstract
The investigation of personality genetics had received much attention since the three seminal reports showing an association between genes and personality traits in the general population. Accumulating evidences suggested that personality traits have significant genetic components. Although currently available data are not enough for proof, more and more genetic variants associated with personality traits are being discovered. In this paper, we review related studies of gene polymorphisms and human personality traits for psychiatric, behavioral, and substance-related disorders. First, we briefly describe the commonly-used self-reported temperament measures that define personality dimensions. Then, we summarize the characteristics of the candidate genes for personality traits, and investigate gene variants which have been suggested to be linked with personality traits for individuals with psychiatric, behavioral, and substance-related disorders
Keywords: Molecular genetics, personality, psychiatric disorders, temperament measures.
Article Information
Article History:
Received Date: 3/12/2008
Revision Received Date: 13/2/2009
Acceptance Date: 16/2/2009
Electronic publication date: 6
/3/2009
Collection year: 2009
© Lin and Chen; Licensee Bentham Open.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (
http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to these authors at the Vita Genomics, Inc., 7 Fl., No. 6, Sec. 1, Jung-Shing Road, Wugu Shiang, Taipei, Taiwan; Tel: (+ 886) 2-8976-9123 ext, 7751; Fax: (+ 886) 2-8976-9523; E-mail: eugene.lin@vitagenomics.comCorrespondence:
Department of Psychiatry, National Cheng Kung University, Tainan, Taiwan;
Tel: (+ 886) 6-235-3535 ext, 5190; Fax: (+ 886) 6-275-9259;
E-mail: chenps@mail.ncku.edu.tw
Open Peer Review Details |
Manuscript submitted on 3-12-2008 |
Original Manuscript |
Molecular Genetics of Human Personality Traits for Psychiatric, Behavioral, and Substance-Related Disorders |