Correlation Between Non-Alcoholic Fatty Liver and Chronic Kidney Disease
Hasyim Kasim1, *, St. Rabiul Zatalia1, Haerani Rasyid1, Syakib Bakri1, Muhammad L. Parewangi2, Fardah Akil2, Arifin Seweng3
1 Nephrology Hypertension Division of Internal Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
2 Gastroenterohepatology Division of Internal Medicine Department, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
3 Biostatistics Public Health Faculty, Hasanuddin University, Makassar, Indonesia
NAFLD is an independent risk factor of CKD. CKD prevalences in NAFLD subjects are two times higher than non-NAFLD. The aim of this study is to know the correlation between NAFLD and CKD.
Cross-sectional study was conducted on patients who held Abdominal USG in Wahidin Sudirohusodo & UNHAS hospital from January to December 2017. NAFLD subjects are male and female (18-60 years) who met NAFLD criteria and wanted to participate, non-NAFLD as control subjects. NAFLD is fat accumulation in hepatocyte without a history of alcohol consumption or other etiology of chronic liver disease. CKD definition and classification were based on KDIGO 2012. P value <0.05 was considered to be significant.
From the study period, we found 134 subjects (67 NAFLD subjects and 67 non-NAFLD subjects). Correlation analysis between NAFLD and eGFR showed that NAFLD subjects had more proportion of eGFR <60 ml/min/1.73m2 than non-NAFLD subjects (40.3% vs 16.4%, p=0.002). NAFLD subjects significantly had more proportion of CKD Grade 3 than non-NAFLD subjects (37.3% vs 9%) while non-NAFLD subjects had more proportion of CKD Grade 1 and 2 than NAFLD subjects (56.7% vs 38.8% dan 26.9% vs 20.9%)(p=0.001). Correlation analysis between NAFLD and proteinuria did not show significant results (p=0.051).
NAFLD subjects correlated with CKD events compared with non-NAFLD subjects.
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* Address correspondence to this author at the Nephrology Hypertension Division of Internal Medicine Department, Faculty of Medicine Hasanuddin University, Makassar, Indonesia; E-mail: email@example.com