1 Natubhai V. Patel College of Pure and applied Science, Vallabh Vidyanagar, Gujarat – 388120, India
Nitriles are organic compounds having −C≡N group. They are frequently known to occur in nature and as an intermediate byproducts and waste products of various chemical, pharmaceutical and agricultural industries. They are also found in fruit pits, cabbage, cauliflower and sprouts, which get released upon hydrolysis. Nitrile converting enzymes like nitrilases have been extracted from microorganisms and plants. Nitrilase mediated biocatalysis reactions have continuously aroused widespread interest to scientists and entrepreneurs in organic synthesis. Nitrile converting biocatalysts (Nitrilases) are now of substantial industrial interest from the perspective of treating toxic nitrile and cyanide containing compounds. Nitrile degrading enzymes generally consist of nitrilases and amidases. The aim of the current review is to summarize the recent advancements on regioselective nitrilases concerning their fundamental researches and their application in synthesis of series of high value fine chemicals and pharmaceuticals. The present review also focuses on the utility of nitrile converting enzyme, sources, properties, classification, structure and applications as well.
Keywords: - Nitrilase, Nitrile, Biocatalysis, Bioremediation, Green chemistry.
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