Table 1:
EC50 Values of four Gq-Coupled GPCRs Determined in the IP-One and Intracellular Calcium Assays
GPCR
Agonist
EC
50
(nM) (calcium assay) (a)
EC
50
(nM) (IP-One assay) (b)
Ratio b/a
M
1
R
Carbachol
16.1
535
33.2
V1bR
Vasopressin
0.032
1.10
34.4
FFAR1
GW9508
5700
6300
1.1
NPSR
NPS
0.22
0.41
1.9