Table 1: Comparison of disease symptoms and characteristics for Wolman Disease vs. Cholesteryl Ester Storage Disease.

Disease Symptoms/Characteristics Wolman Disease Cholesteryl Ester Storage Disease
Lipid Profile Elevated LDL-cholesterol, triglycerides. Reduced levels of HDL Elevated LDL-cholesterol, triglycerides, serum total cholesterol [16] Reduced levels of HDL
Liver Function Elevated ALT + AST Elevated ALT + AST
Hepatic Pathology Yellow and greasy. Infiltration by lipid-filled Kupffer cells [30]. Fibrosis. Microvesicular steatosis of the hepatocytes. Cirrhosis. Infiltration by lipid-filled Kupffer cells and macrophages [36]
Splenic Pathology Enlarged spleen [27] Enlarged spleen [11]
Adrenal Pathology Calcification of the adrenal glands [25] Very rare calcification of the adrenal glands [16]
Intestinal Pathology Massive CE and TG accumulation in the small intestine. Infiltration of the lamina propria by foamy macrophages [34] CE accumulation, but to a much lesser degree than WD [16]
Biochemical Features No functioning levels of LAL [34] 1-12% of functioning LAL relative to healthy patients [11]
Age of Onset First few months of birth [34] Childhood to Adulthood [16]
Life Expectancy <1 year [34] Patients live into adulthood [16]
Causes of Death Malnutrition, malabsorption, liver failure [34] Liver failure [16]