Table 1: Cytotoxicity of well-characterized human nephrotoxicants in HK-2 and SA7K Cells.
| Nephrotoxicants |
Cell viability (IC50, µM) |
Caspase 3/7 (EC50, µM) |
MMP (IC50, µM) |
|
HK-2 |
SA7K |
HK-2 |
SA7K |
HK-2 |
SA7K |
| Cyclosporine A |
19.92±4.17 |
Inactive |
Inactive |
11.12±1.80 |
Inactive |
10.34±1.86 |
| Potassium dichromate |
65.75±14.83 |
18.65±5.27 |
Inactive |
23.39±1.90 |
Inactive |
72.54±4.91 |
| Cadmium (II) chloride |
26.98±4.60 |
65.23±11.73 |
Inactive |
Inactive |
Inactive |
Inactive |
| Citrinin |
78.2±0 |
87.75±0 |
Inactive |
98.46± 0 |
78.56±9.03 |
73.96±6.01 |
| Adefovir dipivoxil |
64.65±4.38 |
91.71±11.69 |
63.23±14.46 |
84.57±5.51 |
Inactive |
78.21±0 |
| Puromycin |
1.30±0.64 |
3.95±0.64 |
3.37±0.22 |
2.55±0.82 |
Inactive |
5.28±2.68 |
| Arsenic trioxide |
13.15±1.07 |
17.19±4.29 |
Inactive |
15.16±6.0 |
Inactive |
Inactive |
| Rifampin |
84.57±5.51 |
69.70±0 |
Inactive |
82.98±6.75 |
26.89±3.70 |
15.67±5.70 |
| Tacrolimus |
Inactive |
Inactive |
Inactive |
Inactive |
49.93±0 |
22.30±0 |
| Tetracycline |
Inactive |
Inactive |
Inactive |
Inactive |
Inactive |
9.85±0 |
Data are presented as mean ± SD from two to three experiments. Compounds showing no concentration response were defined as inactive.