Table 2: Evaluation of nephrotoxic compounds in HK-2 and SA7K Cells.
Compounds |
Cell viability (IC50, µM) |
Caspase 3/7 (EC50, µM) |
MMP (IC50, µM) |
|
HK-2 |
SA7K |
HK-2 |
SA7K |
HK-2 |
SA7K |
Camptothecin |
0.69±0.09 |
0.75±0.14 |
0.47±0.05 |
1.92±0.54 |
6.26±0.51 |
14.54±3.63 |
Sunitinib malate |
18.03±3.09 |
12.65±3.06 |
Inactive |
7.33±1.78 |
Inactive |
Inactive |
Sulfinpyrazone |
22.21±1.81 |
Inactive |
Inactive |
Inactive |
14.82±1.28 |
11±4.15 |
Mitomycin C |
10.11±0.66 |
7.53±2.90 |
23.79±4.44 |
6.38±0.42 |
Inactive |
Inactive |
Vinblastine Sulfate |
Inactive |
Inactive |
Inactive |
0.57±1.86 |
Inactive |
Inactive |
Doxorubicin |
3.89±0.50 |
2.51±0.74 |
2.64±0.79 |
2.75±0.35 |
0.39±0.19 |
1.18±0.51 |
Taxol |
Inactive |
Inactive |
0.04±0.01 |
0.67±0.29 |
34.08±4.45 |
35.87±2.34 |
Ochratoxin A |
0.04±0 |
17.00±1.38 |
0.15±0.06 |
Inactive |
Inactive |
Inactive |
Ergotamine |
Inactive |
Inactive |
Inactive |
Inactive |
17.64±1.43 |
16.16±2.75 |
Digoxin |
0.03±0.008 |
0.61±0.19 |
Inactive |
Inactive |
Inactive |
Inactive |
Data are presented as mean ± SD from two to three experiments.