Table 2: Evaluation of nephrotoxic compounds in HK-2 and SA7K Cells.

Compounds Cell viability (IC50, µM) Caspase 3/7 (EC50, µM) MMP (IC50, µM)
HK-2 SA7K HK-2 SA7K HK-2 SA7K
Camptothecin 0.69±0.09 0.75±0.14 0.47±0.05 1.92±0.54 6.26±0.51 14.54±3.63
Sunitinib malate 18.03±3.09 12.65±3.06 Inactive 7.33±1.78 Inactive Inactive
Sulfinpyrazone 22.21±1.81 Inactive Inactive Inactive 14.82±1.28 11±4.15
Mitomycin C 10.11±0.66 7.53±2.90 23.79±4.44 6.38±0.42 Inactive Inactive
Vinblastine Sulfate Inactive Inactive Inactive 0.57±1.86 Inactive Inactive
Doxorubicin 3.89±0.50 2.51±0.74 2.64±0.79 2.75±0.35 0.39±0.19 1.18±0.51
Taxol Inactive Inactive 0.04±0.01 0.67±0.29 34.08±4.45 35.87±2.34
Ochratoxin A 0.04±0 17.00±1.38 0.15±0.06 Inactive Inactive Inactive
Ergotamine Inactive Inactive Inactive Inactive 17.64±1.43 16.16±2.75
Digoxin 0.03±0.008 0.61±0.19 Inactive Inactive Inactive Inactive

Data are presented as mean ± SD from two to three experiments.