Fig. (3) I/R mice have higher levels of proinflammatory cytokines in both myocardium and plasma. Adult mice were treated with vit D (0.5 mg/kg, iv) or vehicle. Levels of cytokines (IL1β, IL-6, and TN-α) were analyzed by ELISA 72 h after reperfusion. Vit D treated mice had lower levels of cytokines in plasma (A) and myocardial tissue (B). Data are expressed as mean ± standard error. *P <0.05 versus corresponding sham; **P <0.05 versus I/R and vehicle treated mice.