Table 1: Mice were treated with vit D 72hr I/R. Untreated and vehicle mice displayed significantly reduced left ventricle (LV) function, including developed pressure, ejection fraction and cardiac output, compared with sham mice. Treatment with vitamin D improved LV function. Data are expressed as mean ± standard error, n = 8 in each group; *P <0.05 versus corresponding sham; **P <0.05 versus vitamin D treatment.
| Sham |
Cardiac Ischemia/Reperfusion |
| - |
- |
Untreated |
Vehicle |
vit D |
| Heart rate (bpm) |
430±3 |
492±5* |
495±6* |
487±4* |
| Ejection fraction (%) |
65.4±3.1 |
29.1±3.9* |
28.8±4.2* |
52.3±4.2** |
| LVEDP (mmHg) |
3.4±0.3 |
7.5±0.3* |
7.8±0.5* |
4.8±0.5** |
| LVSP (mmHg) |
110.2±4.3 |
3.5.3±2.4* |
3.4±0.5* |
89.3±4.2** |
| Cardiac output |
5.9±0.4 |
2.7±0.2* |
2.8±0.5* |
4.2±1.2** |