Table 2: Aberrantly expressed miRNA and their reported target genes.

S.N	miRNAs	Validated Gene targets	Function of miRNAs	Expression of miRNAs	References
1	miR-21	PTEN, RECK, PDCD4	Anti-apoptotic activity, promotes metastasis and invasion		[122, 123]
2.	miR-106b	E2F1, RhoGTPases, RhoA, RhoC	Promotes cell migration and actin stress fibre formation		[120]
3.	miR-17-5p	p38, MAPK pathway, E2F-1, c-MYC	Promotes malignancy and metastasis		[2, 124]
4.	miR- 151	RhoGDIA, FAK,	Promotes tumour metastasis and invasion		[125, 126]
5.	miR-122	CyclinG1, ADAM10, SRF, IGF1R, PTTG1, PBF, CUTL1,NDRG3,MDR-1	Responsible for inhibition of virus replication and cell proliferation		[127, 128]
6.	miR-143	FNDC3B	Promotes tumour metastasis		[129]
7.	miR-210	VMP1	Promotes hypoxia induced epithelial to mesenchymal transition		[130]
8.	miR-29	MEG3, Bcl-2, Mcl-1	Promotion of apoptosis and inhibition of tumour growth		[119]
9.	let-7	cMyc, p16, Bcl-xl, COLIA2	Inhibit cell growth and proliferation		[131]
10.	miR-26a	Cyclin D2, Cyclin E2, Cyclin E1,CDK6, IL-6	Inhibit metastasis, invasion and tumour growth		[132]
11.	miR-221	CDKN1B/p27,CDKN1C/p57, DDIT4,PTEN, Bmf, TIMP3, PPP2R2A	Anti-apoptotic, help in metastasis and tumour growth.		[118, 133]
12.	miR-1	FoxP1, MET, HDAC4	Inhibition of cell growth and reduced replication potential		[134]
13.	miR-195	cyclin D1, CDK6, E2F3, LATS2,VEGF, VAV2, CDC42, IKKα and TAB3, TNF-α/NF-κB pathway	Inhibit metastasis, G1/S transition, angiogenesis and helps in apoptosis.		[135]
14.	miR-45	OCT4, IRS1, IRS2, IGF signaling,HDAC2	Inhibit cell proliferation, migration, and invasion		[136, 137]
15.	miR-224	API-5, CDC42, CDH1, PAK2, BCL-2,MAPK1, PPP2R1B. .	Promote cell proliferation,migration, invasion, andinhibit cell apoptosis		[138, 139]