Inhibition of Inducible Nitric Oxide Synthase Expression by a Novel Small Molecule Activator of the Unfolded Protein Response

Fig. (1). Chemical structure of screening hit and inactive analog Compound 1, a synthetic 3-trifluoromethyl-N-methylpyrazole, MW=349.76, inhibits cellular iNOS activity. Compound 2, 3-methyl-N-methylpyrazole, MW=295.79, a structural analog of Compound 1, is inactive in cellular iNOS inhibition assays.