Table 1: Summary of Compound Potencies (µM) with Known Activity in the CREB pathway identified from screening of the LOPAC library in qHTS

Name First Run Second Run Third Run Mean ± SD
Forskolin 0.32 0.25 0.25 0.27±0.04
8-(4-Chlorophenylthio)-cAMP 25.12 25.12 15.85 22.03±5.35
8-Bromo-cAMP 25.12 15.85 25.12 22.03±5.35
Papaverine hydrochloride 1.58 0.79 0.79 1.06±0.46
Trequinsin (HL-725) 2.51 1.58 1.26 1.79±0.65
Rolipram 1.26 1.26 2.00 1.50±0.43
Ro 20-1724 5.01 12.59 2.00 6.53±5.46
Etazolate hydrochloride 12.59 15.85 15.85 14.76±1.88
Ibudilast 10.00 12.59 12.59 11.73±1.49
Tracazolate 5.01 5.01 5.01 5.01±0.00
T-1032 12.59 12.59 12.59 12.59±0.00
3-Isobutyl-1-methylxanthine 8-Methoxymethyl-3-isobutyl- 15.85 15.85 15.85 15.85±0.00
1-methylxanthine 25.12 15.85 15.85 18.94±5.35
Propentofylline 25.12 25.12 15.85 22.03±5.35
Zardaverine 10.00 15.85 12.59 12.81±2.93