Development of a Cell-Based High-Throughput Assay to Screen for Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3

Fig. (2) Time dependent uptake of FMTX into CHO cells expressing OATP1B1 and OATP1B3. Uptake of 10 µM FMTX was determined at 37 ^°C with wild-type (closed triangles), OATP1B1 (open circles) or OATP1B3 (closed circles) expressing CHO cells on 24-well plates. Values are means ± SE of quadruplicate determinations in a single experiment.