Table 2: IC50 Values for Screening Hits (General Library)
| Compound |
unP-IC50 (µM)1
|
P-IC50 value (µM)2
|
Ratio3
|
| Hit 1 |
10.0 |
>100 |
>10 |
| Hit 2 |
14.0 |
>60 |
>4 |
| Hit 3 |
27 |
>100 |
>4 |
| Hit 4 |
19.0 |
>60 |
>3 |
| Hit 5 |
11.0 |
59.0 |
5.4 |
| Hit 6 |
15.0 |
>100 |
>7 |
| Hit 7 |
2.5 |
2.5 |
1 |
| Staurosporine |
0.028 |
0.057 |
2.0 |
| SU11274 |
0.005 |
0.28 |
56.0 |
1IC50 value for the unphosphorylated form of c-Met.
2IC50 value for the phosphorylated form of c-Met.
3Ratio = IC50 value for phosphorylated form / IC50 value for the unphosphorylated form.