Table 3: IC50 Values for Screening Hits (Internal Kinase Inhibitors Collection)
| Compound |
unP-IC50 (µM)1
|
P-IC50 value (µM)2
|
Ratio3
|
| Hit 1 |
>60 |
11 |
<0.2 |
| Hit 2 |
>60 |
4.2 |
<0.1 |
| Hit 3 |
3.5 |
>60 |
>17 |
| Hit 4 |
3.9 |
>60 |
>15.4 |
| Hit 5 |
4.5 |
1.0 |
0.2 |
| Hit 6 |
0.1 |
0.5 |
5 |
| Hit 7 |
>100 |
10 |
<0.1 |
| Hit 8 |
>100 |
4 |
<0.04 |
| Hit 9 |
106 |
8 |
0.08 |
| Hit 10 |
1.4 |
26 |
19 |
| Hit 11 |
4.5 |
220 |
49 |
| Hit 12 |
65 |
3.9 |
0.06 |
| Hit 13 |
1 |
5.7 |
5.7 |
1IC50 value for the unphosphorylated form of c-Met.
2IC50 value for the phosphorylated form of c-Met.
3Ratio = IC50 value for phosphorylated form / IC50 value for the unphosphorylated form