Fig. (1) Schematics of ARE-luciferase and AREmut-luciferase reporter genes. ARE-luciferase reporter gene (A) contains seven multimerized consensus AREs upstream of a basic promoter containing CCAAT and TATA boxes that drive the expression of firefly luciferase. The AREmut-luciferase reporter is identical to the ARE-luciferase reporter except that six core nucleotides within each ARE have been mutated (mutated bases underlined).