Table 1: Nrf2 Activation Potency of Metals in Reporter Cell Lines CD (uM)

Compound HEK293T HepG2 MCF7 A172 A549
HQ 7.12 20.8 # 33.2 NR*
Au 76.1 169 740 146 NR
As 1.88 16.5 9.05 15.9 123
Ag 11.8 2.52 4.73 5.54 NR
Cd .907 .954 11 6.03 54.7
Co 484 185 532 NR NR
Cu 281 455 295 136 392
Fe # # NR 239 NR
Hg 2.82 19.5 6.35 6.18 NR
Pb # 426 # # NR
Zn 84.8 249 256 100 NR
OPD 16.8 110 42.7 46.6 NR

* No response,
# Calculated CD exceeds empirically tested concentration range.