B

Family Kinase Kinase concentration (nM) polyGT polyGAT CDK1 IRS1 JAK1
ALK ALK 4 9.8 7.2 2.6 16.8 3.9
AXL AXL 4 9.8 5.6 1.5 1.6 1.2
DDR DDR1 0.5 2.0 3.0 1.0 1.1 1.0
DDR DDR2 0.5 4.1 5.1 1.0 4.9 1.0
EGFR EGFR 0.5 1.7 5.0 1.8 2.5 19
EGFR EGFR [T790M] 0.5 18.1 10.8 1.1 1.2 3.9
EPH EphA1 0.5 24.1 11.4 3.1 1.2 1.2
EPH EphA2 0.25 12.3 7.1 2.1 1.8 3.9
EPH EphA3 0.5 17.4 8.0 4.4 3.5 3.8
EPH EphA4 0.5 12.6 11.3 6.7 2.4 6.4
EPH EphA5 1 18 21.9 19.2 7.6 21.2
EPH EphA6 0.5 14.2 15.5 1.2 1.1 1.3
EPH EphA7 0.5 22.7 11.1 1.4 1.3 1.5
EPH EphA8 0.25 16.4 7.8 3.1 1.6 5.6
EPH EphB1 0.5 25.1 7.9 14.1 8.4 10.6
EPH EphB2 0.25 27.9 13.2 13.1 3.8 5.7
EPH EphB3 0.1 29 11.2 8.3 2.3 4.0
EPH EphB4 0.5 13.7 4.0 12.6 4.8 12
FGFR FGFR1 0.5 2.9 5.0 1.6 13.5 30.8
FGFR FGFR2 0.25 7.8 11.6 1.6 15.5 33.2
FGFR FGFR3 0.25 16 10.7 1.4 8.1 27.6
FGFR FGFR4 3 9.2 5.6 1.2 3.4 20.8
VEGFR FLT1 0.25 22.2 15.4 1.1 1.9 10
PDGFR FLT3 0.1 20.8 13.2 3.6 4.5 25
VEGFR FLT4 0.25 6.9 6.5 1.8 11.4 36.9
PDGFR FMS (CSFR) 0.25 14.6 6.2 1.2 1.4 6.3
EGFR HER2 10 9.3 8.4 1.1 1.1 1.4
EGFR HER4 (ERBB4) 0.1 25.2 14.4 1.1 1.1 1.5
INSR IGF1R 0.25 21.8 14.6 3.1 15.2 12.8
INSR INSR 20 18.3 25.4 1.1 3.2 1.6
INSR IRR 0.5 21.6 9.1 2.4 15.6 12.7
VEGFR KDR 0.25 8.6 4.3 1.3 5.1 30.8
PDGFR KIT 2 13 21.7 1.0 1.0 3.3
ALK LTK 1 21.3 25.1 2.4 3.9 2.7
AXL MER 0.25 29.2 15.9 9.7 5.6 3.2
MET MET 0.5 17 13.2 4.1 4.5 19.7
MUSK MUSK 1 2.5 10.6 1.8 1.1 3.9
PDGFR PDGFRA 0.5 17.8 10.6 1.3 2.4 9.0
PDGFR PDGFRB 0.25 11.2 12.5 1.6 2.0 3.0
RET RET 0.5 1.4 3.2 1.5 6.9 23.6
MET RON 0.25 27.7 25.7 1.3 4.4 4.9
ROR ROR1 20 3.4 1.5 0.9 1.0 1.0
ROR ROR2 20 4.2 1.4 1.0 0.9 1.0
ROS ROS 0.25 23.8 9 4.4 20.5 7.7
TIE TIE2 0.5 19.3 9.4 1.6 2.1 5.4
TRK TRKA (NTRK1) 0.5 16.3 17.5 5.5 11.8 15.1
TRK TRKB (NTRK2) 0.5 22.9 26.3 7.0 11.1 17
TRK TRKC (NTRK3) 0.5 34.1 22.3 1.1 1.7 1.4
AXL TYRO3 0.25 21.5 9.1 4.7 4.8 2.1

The S/B ratios for each kinase are tabulated. The results are separated based on kinase type: A) Cytoplasmic or non-receptor Tyr kinases and B) Receptor Tyr kinases. The classification correlates with Robinson et al. [10] and Manning et al. [11].