Family | Kinase | Kinase concentration (nM) | polyGT | polyGAT | CDK1 | IRS1 | JAK1 |
---|---|---|---|---|---|---|---|
ALK | ALK | 4 | 9.8 | 7.2 | 2.6 | 16.8 | 3.9 |
AXL | AXL | 4 | 9.8 | 5.6 | 1.5 | 1.6 | 1.2 |
DDR | DDR1 | 0.5 | 2.0 | 3.0 | 1.0 | 1.1 | 1.0 |
DDR | DDR2 | 0.5 | 4.1 | 5.1 | 1.0 | 4.9 | 1.0 |
EGFR | EGFR | 0.5 | 1.7 | 5.0 | 1.8 | 2.5 | 19 |
EGFR | EGFR [T790M] | 0.5 | 18.1 | 10.8 | 1.1 | 1.2 | 3.9 |
EPH | EphA1 | 0.5 | 24.1 | 11.4 | 3.1 | 1.2 | 1.2 |
EPH | EphA2 | 0.25 | 12.3 | 7.1 | 2.1 | 1.8 | 3.9 |
EPH | EphA3 | 0.5 | 17.4 | 8.0 | 4.4 | 3.5 | 3.8 |
EPH | EphA4 | 0.5 | 12.6 | 11.3 | 6.7 | 2.4 | 6.4 |
EPH | EphA5 | 1 | 18 | 21.9 | 19.2 | 7.6 | 21.2 |
EPH | EphA6 | 0.5 | 14.2 | 15.5 | 1.2 | 1.1 | 1.3 |
EPH | EphA7 | 0.5 | 22.7 | 11.1 | 1.4 | 1.3 | 1.5 |
EPH | EphA8 | 0.25 | 16.4 | 7.8 | 3.1 | 1.6 | 5.6 |
EPH | EphB1 | 0.5 | 25.1 | 7.9 | 14.1 | 8.4 | 10.6 |
EPH | EphB2 | 0.25 | 27.9 | 13.2 | 13.1 | 3.8 | 5.7 |
EPH | EphB3 | 0.1 | 29 | 11.2 | 8.3 | 2.3 | 4.0 |
EPH | EphB4 | 0.5 | 13.7 | 4.0 | 12.6 | 4.8 | 12 |
FGFR | FGFR1 | 0.5 | 2.9 | 5.0 | 1.6 | 13.5 | 30.8 |
FGFR | FGFR2 | 0.25 | 7.8 | 11.6 | 1.6 | 15.5 | 33.2 |
FGFR | FGFR3 | 0.25 | 16 | 10.7 | 1.4 | 8.1 | 27.6 |
FGFR | FGFR4 | 3 | 9.2 | 5.6 | 1.2 | 3.4 | 20.8 |
VEGFR | FLT1 | 0.25 | 22.2 | 15.4 | 1.1 | 1.9 | 10 |
PDGFR | FLT3 | 0.1 | 20.8 | 13.2 | 3.6 | 4.5 | 25 |
VEGFR | FLT4 | 0.25 | 6.9 | 6.5 | 1.8 | 11.4 | 36.9 |
PDGFR | FMS (CSFR) | 0.25 | 14.6 | 6.2 | 1.2 | 1.4 | 6.3 |
EGFR | HER2 | 10 | 9.3 | 8.4 | 1.1 | 1.1 | 1.4 |
EGFR | HER4 (ERBB4) | 0.1 | 25.2 | 14.4 | 1.1 | 1.1 | 1.5 |
INSR | IGF1R | 0.25 | 21.8 | 14.6 | 3.1 | 15.2 | 12.8 |
INSR | INSR | 20 | 18.3 | 25.4 | 1.1 | 3.2 | 1.6 |
INSR | IRR | 0.5 | 21.6 | 9.1 | 2.4 | 15.6 | 12.7 |
VEGFR | KDR | 0.25 | 8.6 | 4.3 | 1.3 | 5.1 | 30.8 |
PDGFR | KIT | 2 | 13 | 21.7 | 1.0 | 1.0 | 3.3 |
ALK | LTK | 1 | 21.3 | 25.1 | 2.4 | 3.9 | 2.7 |
AXL | MER | 0.25 | 29.2 | 15.9 | 9.7 | 5.6 | 3.2 |
MET | MET | 0.5 | 17 | 13.2 | 4.1 | 4.5 | 19.7 |
MUSK | MUSK | 1 | 2.5 | 10.6 | 1.8 | 1.1 | 3.9 |
PDGFR | PDGFRA | 0.5 | 17.8 | 10.6 | 1.3 | 2.4 | 9.0 |
PDGFR | PDGFRB | 0.25 | 11.2 | 12.5 | 1.6 | 2.0 | 3.0 |
RET | RET | 0.5 | 1.4 | 3.2 | 1.5 | 6.9 | 23.6 |
MET | RON | 0.25 | 27.7 | 25.7 | 1.3 | 4.4 | 4.9 |
ROR | ROR1 | 20 | 3.4 | 1.5 | 0.9 | 1.0 | 1.0 |
ROR | ROR2 | 20 | 4.2 | 1.4 | 1.0 | 0.9 | 1.0 |
ROS | ROS | 0.25 | 23.8 | 9 | 4.4 | 20.5 | 7.7 |
TIE | TIE2 | 0.5 | 19.3 | 9.4 | 1.6 | 2.1 | 5.4 |
TRK | TRKA (NTRK1) | 0.5 | 16.3 | 17.5 | 5.5 | 11.8 | 15.1 |
TRK | TRKB (NTRK2) | 0.5 | 22.9 | 26.3 | 7.0 | 11.1 | 17 |
TRK | TRKC (NTRK3) | 0.5 | 34.1 | 22.3 | 1.1 | 1.7 | 1.4 |
AXL | TYRO3 | 0.25 | 21.5 | 9.1 | 4.7 | 4.8 | 2.1 |