Fig. (5) Concentration response curves of TNF-α inhibitors in a HTRF-based TNF-α assay (▼) and ELISA-based assay (■). TNF-α level was measured after THP-1 cells were incubated with various concentrations of Bay 11-7085 (A), CCG-2046 (B), IRAK-1/4 inhibitor (C) and PD 169316 (D) in the presence of 1 µg/ml LPS for 17 hr