Fig. (10) Superimposition of various cofactor (SAM or SAH) conformations extracted from currently available crystal structures. A) Structures of cofactors bound to nine human PKMTs, including G9a (PDB: 3K5K), GLP (PDB: 3MO0), SETMAR (PDB: 3BO5), SUV39H2 (PDB: 2R3A), SETD2 (PDB: 3H6L), SMYD3 (PDB: 3MEK), MLL (PDB: 2W5Z), SET7/9 (PDB: 1O9S) and SETD8 (PDB: 1ZKK). B) Structures of cofactors bound to human DOT1L (PDB: 1NW3) and three human PRMTs, including PRMT4 (CARM1) (PDB: 2V74), PRMT1 (PDB: 1ORI) and PRMT3 (PDB: 2FYT).