Table 4: EC50 Values for the 16 Hits Across all Four Assay Formats

Compound # BLA M_BLA FLIPR M_FLIPR
EC50 %Activity EC50 %Activity EC50 %Activity EC50 %Activity
40 18.9 113.9 31.9 87.7 4.54 75.6 5.20 83.3
144 248.9 84.2 807 36.8 8.19 103.5 15.6 85.2
148 0.097 100.4 0.371 103.8 0.046 113.9 0.106 89.6
202 38.5 96.6 50.7 65.1 1.36 91.1 0.575 82.7
205 69.8 51.7 109 37.9 31.4 73.8 6.87 94.5
234 772.6 59.4 1900 46.0 204.9 66.8 205 66.5
237 378.0 74.0 256 54.1 18.7 105.3 18.8 104.4
240 2.95 139.3 7.83 102.4 0.333 97.7 0.329 96.9
241 850.2 59.2 1100 30.4 355.7 52.1 356 51.9
243 871.4 65.9 679 39.1 364.6 74.5 365 73.8
248 1.10 116.3 8.48 74.9 0.082 105.2 0.082 104.0
249 0.599 119.9 0.671 77.1 0.065 76.8 0.065 78.0
250 0.810 111.0 0.764 102.6 0.009 96.2 0.009 97.7
251 0.955 97.5 0.350 98.0 0.037 105.9 0.037 107.5
252 0.950 147.2 0.433 104.5 0.056 99.1 0.056 95.6
253 0.020 91.2 0.093 115.7 0.040 115.2 0.040 116.9