Table 4: EC50 Values for the 16 Hits Across all Four Assay Formats
Compound # |
BLA |
M_BLA |
FLIPR |
M_FLIPR |
|
EC50
|
%Activity |
EC50
|
%Activity |
EC50
|
%Activity |
EC50
|
%Activity |
40 |
18.9 |
113.9 |
31.9 |
87.7 |
4.54 |
75.6 |
5.20 |
83.3 |
144 |
248.9 |
84.2 |
807 |
36.8 |
8.19 |
103.5 |
15.6 |
85.2 |
148 |
0.097 |
100.4 |
0.371 |
103.8 |
0.046 |
113.9 |
0.106 |
89.6 |
202 |
38.5 |
96.6 |
50.7 |
65.1 |
1.36 |
91.1 |
0.575 |
82.7 |
205 |
69.8 |
51.7 |
109 |
37.9 |
31.4 |
73.8 |
6.87 |
94.5 |
234 |
772.6 |
59.4 |
1900 |
46.0 |
204.9 |
66.8 |
205 |
66.5 |
237 |
378.0 |
74.0 |
256 |
54.1 |
18.7 |
105.3 |
18.8 |
104.4 |
240 |
2.95 |
139.3 |
7.83 |
102.4 |
0.333 |
97.7 |
0.329 |
96.9 |
241 |
850.2 |
59.2 |
1100 |
30.4 |
355.7 |
52.1 |
356 |
51.9 |
243 |
871.4 |
65.9 |
679 |
39.1 |
364.6 |
74.5 |
365 |
73.8 |
248 |
1.10 |
116.3 |
8.48 |
74.9 |
0.082 |
105.2 |
0.082 |
104.0 |
249 |
0.599 |
119.9 |
0.671 |
77.1 |
0.065 |
76.8 |
0.065 |
78.0 |
250 |
0.810 |
111.0 |
0.764 |
102.6 |
0.009 |
96.2 |
0.009 |
97.7 |
251 |
0.955 |
97.5 |
0.350 |
98.0 |
0.037 |
105.9 |
0.037 |
107.5 |
252 |
0.950 |
147.2 |
0.433 |
104.5 |
0.056 |
99.1 |
0.056 |
95.6 |
253 |
0.020 |
91.2 |
0.093 |
115.7 |
0.040 |
115.2 |
0.040 |
116.9 |