Synthesis and Biological Evaluation of Novel Antihypertensive Compounds

Scheme 3. Synthesis of compound 3^a ^aReagents and conditions: (a) 1-bromobutane (1.5 equiv.), K₂CO₃ (1.5 equiv.), KI (10 mol%), DMF, rt, 48h, 63%; (b) 5-(4'-bromomethyl-biphenyl-2-yl)-1-trityl-1H-tetrazole (5) (1.1 equiv.), K₂CO₃ (1.5 equiv.), KI (5 mol%), DMF, rt 72h, 92%; (c) MeOH, reflux, 28h, 48%; (d) KHCO₃ (1.0 equiv.), MeOH, reflux, 18h, 78%.