The Synthesis of a Novel Anticancer Compound, N-(3,5 Dimethoxyphenyl) Acridin-9-Amine and Evaluation of Its Toxicity

Table 7: Serum biochemical data for male and female mice orally administered G4 at different concentrations for 14 days.

Parameters	Sex	Control mean ± SD	500 mg/kg mean ± SD	1000 mg/kg mean ± SD
Sodium mmol/L	Male	151±1.22	152±0.23	152.6±3.13
Sodium mmol/L	Female	149±0.55	149.6±0.54	149±2.5
Potassium mmol/L	Male	5.8±0.5	4.6±1.4	5.01±0.39
Potassium mmol/L	Female	4±0.7	4.84±0.5	4±1.21
Chloride mmol/L	Male	108.8±1.64	107±0.2	107.6±2.3
Chloride mmol/L	Female	110±2.7	110.2±1.1	109±0.68
Carbon Dioxide mmol/L	Male	13.4±4.5	13±2.1	13.6±2.9
Carbon Dioxide mmol/L	Female	19±2.41	18±2.9	19±3.2
Anion Gap mmol/L	Male	34.8±3.8	33.7±0.9	35.2±2.4
Anion Gap mmol/L	Female	27±0.55	27±0.11	28.1±1.89
Urea nitrogen mmol/L	Male	8.26±0.7	9±0.76	8.86±1.32
Urea nitrogen mmol/L	Female	8±0.8	8.8±1.3	8.6±1.2
Creatinine mmol/L	Male	8±0	8±0	8±0
Creatinine mmol/L	Female	9±0.5	9±0.2	8±0.23
Albumin g/L	Male	27.2±2.6	28±3.1	27±1.2
Albumin g/L	Female	27±1.7	27±0.24	28±3.1
Total Bilirubin umol/L	Male	1±0	1±0	1.4±0.55
Total Bilirubin umol/L	Female	1±0.2	1±0.23	1±0.9
Alkaline Phosphatase IU/L	Male	61.4±0.5	74±0	75.2±8.6
Alkaline Phosphatase IU/L	Female	67±6.5	68±4.1	66.5±3.7
Alanine Aminotransferase IU/L	Male	41.6±0.9	41.1±6.7	42.6±3.2
Alanine Aminotransferase IU/L	Female	34.01±5.3	33.1±0	33.4±1.3
G-Glutamyal Transferase IU/L	Male	4.6±3.2	4±0.6	4.4±1.82
G-Glutamyal Transferase IU/L	Female	2±0.3	2±0.21	3±0.15