|Rethorst et al. ||Examine biomarkers associated with changes in hypersomnia and insomnia.||126 Individuals with MDD.||Individuals were randomly assigned to two groups of aerobic exercise.||Inventory of Depressive
|Reduction of BDNF levels associated with decreased hypersomnia.|
|Giese et al. ||Investigate the serum BDNF level in adults with insomnia and compare them to a control group.||19 Individuals with RLS/PLM
7 patients with RLS
|BDNF levels were collected and correlated with the scores reported in the Insomnia Severity Index.||Insomnia Severity Index.
|Insomniacs exhibit a significantly lower serum BDNF level than controls.|
|Rusch et al. ||Determine the relationship between increased sleep quality and improvement of depressive symptoms.||44 Individuals with insônia.||Subjects underwent a clinical evaluation and blood samples were taken from all participants. Participants were classified into two groups: sleep improved (n = 28) and sleep declined (n = 16).
Participants underwent 4-8 sessions of CBT for insomnia (CBT-I).
|Health-Related Quality of Life (HRQOL)
Pittsburgh Sleep Quality Index (PSQI)
|The promotion of sleep quality is an effective way to improve depression and quality of life.|
|Giese et al. ||Investigate whether the level of stress influences the association of sleep and BDNF levels.||7 Individuals without insomnia and with RLS/PLM
11 Individuals with subclinical insomnia and with RLS/PLM
8 Individuals with insomnia and with RLS.
|Patients underwent clinical evaluation where the data were correlated.||Insomnia Severity Index (ISI)
Perceived Stress Scale (PSS)
|Sleep is a mediator in the relationship stress and BDNF. Sleep disturbance may explain how some people cope well with stress and other people get sick.|