Clinical Practice & Epidemiology in Mental Health




ISSN: 1745-0179 ― Volume 16, 2020
RESEARCH ARTICLE

Attachment in Patients with Bipolar and Unipolar Depression: A Comparison with Clinical and Non-clinical Controls



Angelo Picardi1, *, Mauro Pallagrosi2, Laura Fonzi7, Giovanni Martinotti3, Emanuele Caroppo4, Giulio Nicolò Meldolesi5, Giancarlo Di Gennaro6, Marco De Risi6, Massimo Biondi2
1 Centre of Behavioural Sciences and Mental Health, Italian National Institute of Health, Rome, Italy
2 Department of Human Neuroscience, Sapienza University of Rome, Rome, Italy
3 Department of Neuroscience and Imaging, University “G.d'Annunzio”, Chieti, Italy
4 Department of Mental Health, Rome 2 Local Health Unit, Catholic University of Sacred Heart, Rome, Italy
5 “Neurone” Foundation for Research in Neuropsychobiology and Clinical Neurosciences, Rome, Italy
6 Epilepsy Surgery Unit, IRCCS Neuromed, Pozzilli, Italy
7 Italian Psychoanalytic Society, Rome, Italy

Abstract

Background:

A link between depression and insecure attachment has long been postulated. Although many studies examined the relationship between depressive symptoms and attachment, relatively few studies were performed on patients diagnosed with depression. Also, research on patients with bipolar disorder is scarce.

Objective:

We aimed at testing the association between attachment insecurity and unipolar and bipolar depression.

Methods:

We studied 21 patients with bipolar disorder, current episode depressed, and three age- and sex-matched groups, each consisting of 21 individuals: patients with major depressive disorder, recurrent episode; patients with epilepsy; non-clinical participants. The Experience in Close Relationships questionnaire was used to assess adult attachment style.

Results:

Patients with both bipolar and unipolar depression displayed significantly higher scores on attachment-related avoidance as compared with patients with epilepsy and non-clinical participants. Also, patients with bipolar depression scored significantly higher on attachment-related anxiety than all other groups. In both psychiatric groups, attachment dimensions were not significantly correlated with global clinical severity or severity of depression.

Conclusion:

Despite some study limitations, our results are consistent with some previous studies and provide support to Bowlby's seminal hypothesis that attachment insecurity may predispose to depression. Attachment theory may provide a valuable theoretical framework for future research and for guiding treatment.

Keywords: Unipolar depression, Bipolar disorder, Epilepsy, Emotion regulation, Hyphothesis, Non-clinical controls.


Article Information


Identifiers and Pagination:

Year: 2019
Volume: 15
First Page: 143
Last Page: 152
Publisher Id: CPEMH-15-143
DOI: 10.2174/1745017901915010143

Article History:

Received Date: 25/10/2019
Revision Received Date: 25/11/2019
Acceptance Date: 26/11/2019
Electronic publication date: 31/12/2019
Collection year: 2019

© 2019 Picardi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at Italian National Institute of Health, Centre of Behavioural Sciences and Mental Health, Viale Regina Elena, 299 - 00161 Rome, Italy; Tel: +39 06 49904200; Fax: +39 06 49904182;
E-mail: angelo.picardi@iss.it






1. INTRODUCTION

Depression is a major public health concern. Major depressive disorder and bipolar disorder are quite prevalent in the general population [1Waraich P, Goldner EM, Somers JM, Hsu L. Prevalence and incidence studies of mood disorders: a systematic review of the literature. Can J Psychiatry 2004; 49(2): 124-38.
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] and together account for 3% of the world’s disease burden [2Whiteford HA, Ferrari AJ, Degenhardt L, Feigin V, Vos T. The global burden of mental, neurological and substance use disorders: an analysis from the Global Burden of Disease Study 2010. PLoS One 2015; 10(2)e0116820
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].

A variety of biological, social, and psychological factors contribute to the development of depression [3Costello EJ, Pine DS, Hammen C, et al. Development and natural history of mood disorders. Biol Psychiatry 2002; 52(6): 529-42.
[http://dx.doi.org/10.1016/S0006-3223(02)01372-0] [PMID: 12361667]
-5Vink D, Aartsen MJ, Schoevers RA. Risk factors for anxiety and depression in the elderly: a review. J Affect Disord 2008; 106(1-2): 29-44.
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]. One of the most consistently identified risk factors is family history. Studies using genetically informative designs reported both substantial heritability and significant environmental effects [6Smoller JW, Finn CT. Family, twin, and adoption studies of bipolar disorder. Am J Med Genet C Semin Med Genet 2003; 123C(1): 48-58.
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-8Wray NR, Gottesman II. Using summary data from the danish national registers to estimate heritabilities for schizophrenia, bipolar disorder, and major depressive disorder. Front Genet 2012; 3: 118.
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], which corroborates the view that family environment factors increase vulnerability to mood disorders.

Given that attachment security is strongly related to early life experiences in the family, attachment may be hypothesised to play a role in shaping individual vulnerability to depression. Indeed, attachment plays a major part in the development of emotion regulation [9Mikulincer M, Shaver PR, Pereg D. Attachment theory and affect regulation: The dynamics, development, and cognitive consequences of attachment-related strategies. Motiv Emot 2003; 27: 77-102.
[http://dx.doi.org/10.1023/A:1024515519160]
] and models of self [10Bretherton I, Munholland KA. Internal working models in attachment relationships: Elaborating a central construct in attachment theory.Handbook of attachment: Theory, research, and clinical applications 2nd ed. 2008; 102-27.], and there are important links between depression, dysfunctional emotion regulation [11Aldao A, Nolen-Hoeksema S, Schweizer S. Emotion-regulation strategies across psychopathology: A meta-analytic review. Clin Psychol Rev 2010; 30(2): 217-37.
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], and dysfunctional schemas about the self [12Beck AT, Rush AJ, Shaw BF, Emery G. Cognitive therapy of depression 1979.].

Attachment theory [13Separation: anxiety and anger Bowlby J. Attachment and loss21973; -15Attachment Bowlby J. Attachment and loss.11969; ] is a life-span developmental theory that postulates that humans have the disposition to build and maintain some intimate social bonds that are critical for survival and good health. The term “attachment” refers to the emotional, cognitive, and behavioural processes involved in the formation and preservation of these bonds. Attachment bonds are first formed with parents. These bonds are maintained across childhood and into adulthood, although from adole- scence onwards committed romantic relationships progres- sively become the primary attachment bond for each person [16Hazan C, Shaver P. Romantic love conceptualized as an attachment process. J Pers Soc Psychol 1987; 52(3): 511-24.
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, 17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.].

According to attachment theory, children develop internal working models of self and others on the basis of early interactions and experiences with their caregivers. These models shape their expectations of how their future relational interactions will play out and also shape the associated emotional and behavioural responses [13Separation: anxiety and anger Bowlby J. Attachment and loss21973; ]. The term “attach- ment style” is used to indicate individual differences in emotion regulation, patterns of relating to significant others, beliefs about self and significant others, and the way significant others are perceived. Research suggests that there are two major dimensions underlying adult attachment style, i.e., attachment-related anxiety and avoidance. The first refers to the fear of being abandoned or not loved enough, the second to discomfort with intimacy and the expression of emotions [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.]. Interestingly, the behaviour of infants during Ainsworth’s “Strange Situation” [18Ainsworth MDS, Blehar MC, Waters E, Wall S. Patterns of attachment:A psychological study of the Strange Situation 1978.] can be mapped onto two conceptually similar dimensions [19Brennan KA, Clark CL, Shaver PR. Self-report measurement of adult attachment: an integrative overview.Attachment theory and close relationships 2008; 46-76.]. Also, these dimensions show theore- tically consistent correlations with the Big Five personality traits, temperament, character, coping, self-esteem, self-efficacy, verbal intelligence, social desirability, physical attrac- tiveness, and relationship satisfaction [20Crowell JA, Fraley RC, Shaver PR. Measurement of individual differences in adolescent and adult attachment.Handbook of attachment: Theory, research, and clinical applications 2nd ed. 2008; 434-65.-22Picardi A, Caroppo E, Toni A, Bitetti D, Di Maria G. Stability of attachment-related anxiety and avoidance and their relationships with the five-factor model and the psychobiological model of personality. Psychol Psychother 2005; 78(Pt 3): 327-45.
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].

Low to moderate levels of both attachment-related anxiety and avoidance characterise secure attachment patterns. In romantic relationships, secure individuals tend to see them- selves as valued and worthy of affection, and their partners as trustworthy, reliable, and available to provide support. Individuals with elevated attachment-related anxiety are characterised by a “hyper-activation” of the attachment system; they are prone to preoccupation with their romantic relation- ships and are inclined to feel underappreciated and to worry about being insufficiently loved or abandoned. Individuals with high attachment-related avoidance are characterised by a “deactivation” of the attachment system; they find it difficult to trust or depend on their partner, are unwilling to ask for support, and prefer to maintain emotional distance [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.].

In his seminal work, Bowlby proposed a link between depression and attachment [14Loss, sadness and depression Bowlby J. Attachment and loss31980; ]. His ideas have subsequently received empirical support from investigations on the long-term effects of adverse attachment-related experiences (e.g., the death of or prolonged separation from a parent in early childhood) on the risk of developing depression later in life. Also, many studies performed on non-clinical samples reported that the security of attachment to parents or peers, secure states of mind with regard to attachment, and endorsement of a secure attachment style in close relationships are related to lower levels of depressive symptoms [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016., 23Stovall-McClough KC, Dozier M. Attachment states of mind and psychopathology in adulthood.Handbook of attachment: Theory, research, and clinical applications 3rd ed. 2015; 715-38.].

However, relatively few studies were performed on clinical samples of adolescent and adult patients with a diagnosis of depression. Most of these investigations involved patients with unipolar depression. While they have consistently reported an association between unipolar depression and attachment insecurity [24Armsden GC, McCauley E, Greenberg MT, Burke PM, Mitchell JR. Parent and peer attachment in early adolescent depression. J Abnorm Child Psychol 1990; 18(6): 683-97.
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-34Rosenstein DS, Horowitz HA. Adolescent attachment and psychopathology. J Consult Clin Psychol 1996; 64(2): 244-53.
[http://dx.doi.org/10.1037/0022-006X.64.2.244] [PMID: 8871408]
], the findings are less consistent regarding the type of insecurity that mostly characterises these patients. Some studies reported that depression was associated with preoccupied states of mind about attachment [26Fonagy P, Leigh T, Steele M, et al. The relation of attachment status, psychiatric classification, and response to psychotherapy. J Consult Clin Psychol 1996; 64(1): 22-31.
[http://dx.doi.org/10.1037/0022-006X.64.1.22] [PMID: 8907081]
, 34Rosenstein DS, Horowitz HA. Adolescent attachment and psychopathology. J Consult Clin Psychol 1996; 64(2): 244-53.
[http://dx.doi.org/10.1037/0022-006X.64.2.244] [PMID: 8871408]
], or that it is attachment anxiety that mostly characterises depression [30Myhr G, Sookman D, Pinard G. Attachment security and parental bonding in adults with obsessive-compulsive disorder: a comparison with depressed out-patients and healthy controls. Acta Psychiatr Scand 2004; 109(6): 447-56.
[http://dx.doi.org/10.1111/j.1600-0047.2004.00271.x] [PMID: 15117290]
, 32Pettem O, West M, Mahoney A, Keller A. Depression and attachment problems. J Psychiatry Neurosci 1993; 18(2): 78-81.
[PMID: 8461287]
]. Other studies reported that depression was associated more closely with dismissing states of mind [28Ivarsson T, Granqvist P, Gillberg C, Broberg AG. Attachment states of mind in adolescents with Obsessive-Compulsive Disorder and/or depressive disorders: a controlled study. Eur Child Adolesc Psychiatry 2010; 19(11): 845-53.
[http://dx.doi.org/10.1007/s00787-010-0120-x] [PMID: 20607573]
, 31Patrick M, Hobson RP, Castle D, Howard R, Maughan B. Personality disorder and the mental representation of early social experience. Dev Psychopathol 1994; 6: 375-88.
[http://dx.doi.org/10.1017/S0954579400004648]
], or highlighted an increase in both anxiety and avoidance [29Marazziti D, Dell’osso B, Catena Dell’Osso M, et al. Romantic attachment in patients with mood and anxiety disorders. CNS Spectr 2007; 12(10): 751-6.
[http://dx.doi.org/10.1017/S1092852900015431] [PMID: 17934379]
, 33Reis S, Grenyer BF. Fear of intimacy in women: relationship between attachment styles and depressive symptoms. Psychopathology 2004; 37(6): 299-303.
[http://dx.doi.org/10.1159/000082268] [PMID: 15564790]
]. The few studies performed on patients with bipolar disorder have consistently reported higher attachment insecurity in these patients as compared with healthy controls [27Fuhr K, Reitenbach I, Kraemer J, Hautzinger M, Meyer TD. Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders. J Affect Disord 2017; 212: 110-6.
[http://dx.doi.org/10.1016/j.jad.2017.01.021] [PMID: 28160683]
, 29Marazziti D, Dell’osso B, Catena Dell’Osso M, et al. Romantic attachment in patients with mood and anxiety disorders. CNS Spectr 2007; 12(10): 751-6.
[http://dx.doi.org/10.1017/S1092852900015431] [PMID: 17934379]
, 35Kökçü F, Kesebir S. [The relationship between attachment style, and temperament, personality and bipolar symptoms: a controlled study on bipolar patients and their children]. Turk Psikiyatr Derg 2010; 21(4): 309-18.
[PMID: 21125506]
-38Rosenfarb IS, Becker J, Khan A. Perceptions of parental and peer attachments by women with mood disorders. J Abnorm Psychol 1994; 103(4): 637-44.
[http://dx.doi.org/10.1037/0021-843X.103.4.637] [PMID: 7822564]
]. However, inconsistent findings have emerged regarding the type of insecurity that mostly characterises these patients [35Kökçü F, Kesebir S. [The relationship between attachment style, and temperament, personality and bipolar symptoms: a controlled study on bipolar patients and their children]. Turk Psikiyatr Derg 2010; 21(4): 309-18.
[PMID: 21125506]
, 37Morriss RK, van der Gucht E, Lancaster G, Bentall RP. Adult attachment in bipolar 1 disorder. Psychol Psychother 2009; 82(Pt 3): 267-77.
[http://dx.doi.org/10.1348/147608309X415309] [PMID: 19288978]
] and from studies comparing bipolar with unipolar depression [26Fonagy P, Leigh T, Steele M, et al. The relation of attachment status, psychiatric classification, and response to psychotherapy. J Consult Clin Psychol 1996; 64(1): 22-31.
[http://dx.doi.org/10.1037/0022-006X.64.1.22] [PMID: 8907081]
, 27Fuhr K, Reitenbach I, Kraemer J, Hautzinger M, Meyer TD. Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders. J Affect Disord 2017; 212: 110-6.
[http://dx.doi.org/10.1016/j.jad.2017.01.021] [PMID: 28160683]
, 29Marazziti D, Dell’osso B, Catena Dell’Osso M, et al. Romantic attachment in patients with mood and anxiety disorders. CNS Spectr 2007; 12(10): 751-6.
[http://dx.doi.org/10.1017/S1092852900015431] [PMID: 17934379]
, 38Rosenfarb IS, Becker J, Khan A. Perceptions of parental and peer attachments by women with mood disorders. J Abnorm Psychol 1994; 103(4): 637-44.
[http://dx.doi.org/10.1037/0021-843X.103.4.637] [PMID: 7822564]
].

While the studies performed so far corroborate an association between attachment and depression, the scarcity of research on patients with bipolar disorder represents an important gap in the literature [39Greenberg S, Rosenblum KL, McInnis MG, Muzik M. The role of social relationships in bipolar disorder: a review. Psychiatry Res 2014; 219(2): 248-54.
[http://dx.doi.org/10.1016/j.psychres.2014.05.047] [PMID: 24947918]
]. Also, the findings are inconsistent regarding the type of insecurity that mostly characterises unipolar and bipolar depression. Furthermore, many studies were hampered by methodological limitations, such as the use of less sophisticated measures of attachment, reliance on clinical diagnoses not confirmed by standardised psychiatric interviews, and lack of control for possible confounding by demographic characteristics, current mood state, or presence of a long-term illness.

We aimed at further testing the hypothesis that attachment insecurity is increased in patients with bipolar and unipolar depression as compared with non-depressed individuals, and at investigating whether there are differences in attachment style between patients with bipolar and unipolar depression. To this purposes, we used validated measures to assess adult attachment style and to establish psychiatric diagnosis, while controlling for demographic characteristics by matching the study groups for age and sex; for current mood state by including in the bipolar and unipolar patient groups only patients who were experiencing a major depressive episode; and for the presence of a long-term illness by including as non-psychiatric comparison groups both a non-clinical group and a group of patients with epilepsy.

2. METHODS

2.1. Participants

The patients with bipolar depression were recruited in the inpatient ward and the outpatient clinic of the psychiatric department of the Umberto I Policlinico Hospital, Sapienza University of Rome, and in a private psychiatric facility situated in the same city. All adult patients of Italian nationality, with no major medical disease or cognitive impairment, who were consecutively admitted to these units over a two-year period and received a diagnosis of bipolar I or II disorder, current episode depressed, were invited to take part in the study. The study was carried out in accordance with the Ethical Code of Conduct of the Italian National Institute of Health with written informed consent from all participants. According to the Italian legislation, purely observational, cross-sectional studies based on data collected as part of routine patient assessment do not need formal ethical approval. However, we decided to still obtain written informed consent from all participants according to the International Ethical Guidelines for Biomedical Research Involving Human Subjects and the Declaration of Helsinki.

Within three days from admission, the participants were administered the Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I) [40First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition 2002 November; ] to establish the diagnosis, the 24-item version of the Brief Psychiatric Rating Scale [41Lukoff D, Nuechterlein KH, Ventura J. Manual for expanded Brief Psychiatric Rating Scale. Schizophr Bull 1986; 12: 594-602.], and the Experience in Close Relationships questionnaire (ECR) [19Brennan KA, Clark CL, Shaver PR. Self-report measurement of adult attachment: an integrative overview.Attachment theory and close relationships 2008; 46-76.].

Three comparison groups were selected. In each group, participants were individually matched to patients with bipolar disorder for sex and age. The first group included patients with major depressive disorder, recurrent episode, who were recruited with the same procedure at the same sites as the patients with bipolar depression, and were administered the same assessment instruments. All of them signed written informed consent to take part in the study.

The second group was recruited among friends and relatives of a number of physicians attending as graduate students the Department of Neurology and Psychiatry, Policlinico Umberto I Hospital, Sapienza University of Rome, Italy. It was a standard non-clinical control group, consisting of individuals who were free from cognitive impairment and severe medical or psychiatric illness as clinically determined. They completed the ECR after giving their written informed consent to take part in the study.

Also, in order to control for the presence of chronic illness, long-term medication treatment, and hospitalization, we included a third comparison group, which included inpatients with drug-resistant epilepsy. They completed the ECR as part of a multidisciplinary presurgical assessment protocol including psychiatric evaluation at the Epilepsy Surgery Unit of the Neuromed-IRCCS Neurological Institute, situated in Pozzilli, about 100 miles east from Rome. Although some patients had depressive or anxiety symptoms, none of them was experiencing a major depressive episode. All patients gave their written informed consent to take part in the study. As such patients are usually young, perfect age matching could not be accomplished. While the age matching was very close for the other two comparison groups, differences of up to 10 years had to be allowed for patients with drug-resistant epilepsy; however, they did not significantly differ in mean age from the other study groups and were close enough in age to provide a good matching.

Table 1 summarises the clinical and demographic characteristics of all study participants.

Table 1
Participant characteristics.


2.2. Assessment Instruments

The ECR questionnaire [19Brennan KA, Clark CL, Shaver PR. Self-report measurement of adult attachment: an integrative overview.Attachment theory and close relationships 2008; 46-76.] is a validated measure of adult attachment style that has been used extensively by researchers in several countries to investigate links between attachment insecurity and a variety of correlates including genetic polymorphisms related to emotions and social behaviour [42Gillath O, Shaver PR, Baek JM, Chun DS. Genetic correlates of adult attachment style. Pers Soc Psychol Bull 2008; 34(10): 1396-405.
[http://dx.doi.org/10.1177/0146167208321484] [PMID: 18687882]
], immune function [43Picardi A, Miglio R, Tarsitani L, et al. Attachment style and immunity: a 1-year longitudinal study. Biol Psychol 2013; 92(2): 353-8.
[http://dx.doi.org/10.1016/j.biopsycho.2012.10.001] [PMID: 23073362]
, 44Gouin JP, Glaser R, Loving TJ, et al. Attachment avoidance predicts inflammatory responses to marital conflict. Brain Behav Immun 2009; 23(7): 898-904.
[http://dx.doi.org/10.1016/j.bbi.2008.09.016] [PMID: 18952163]
], brain activity [45Gillath O, Bunge SA, Shaver PR, Wendelken C, Mikulincer M. Attachment-style differences in the ability to suppress negative thoughts: exploring the neural correlates. Neuroimage 2005; 28(4): 835-47.
[http://dx.doi.org/10.1016/j.neuroimage.2005.06.048] [PMID: 16087352]
] and structure [46Quirin M, Gillath O, Pruessner JC, Eggert LD. Adult attachment insecurity and hippocampal cell density. Soc Cogn Affect Neurosci 2010; 5(1): 39-47.
[http://dx.doi.org/10.1093/scan/nsp042] [PMID: 20007241]
], and vulnerability to physical [47Janković S, Raznatović M, Marinković J, Maksimović N, Janković J, Djikanović B. Relevance of psychosomatic factors in psoriasis: a case-control study. Acta Derm Venereol 2009; 89(4): 364-8.
[http://dx.doi.org/10.2340/00015555-0669] [PMID: 19688147]
, 48Picardi A, Pasquini P, Cattaruzza MS, et al. Psychosomatic factors in first-onset alopecia areata. Psychosomatics 2003; 44(5): 374-81.
[http://dx.doi.org/10.1176/appi.psy.44.5.374] [PMID: 12954911]
] and mental [29Marazziti D, Dell’osso B, Catena Dell’Osso M, et al. Romantic attachment in patients with mood and anxiety disorders. CNS Spectr 2007; 12(10): 751-6.
[http://dx.doi.org/10.1017/S1092852900015431] [PMID: 17934379]
, 49Picardi A, Caroppo E, Fabi E, et al. Attachment and parenting in adult patients with anxiety disorders. Clin Pract Epidemiol Ment Health 2013; 9: 157-63.
[http://dx.doi.org/10.2174/1745017901309010157] [PMID: 24155770]
, 50Tasca GA, Szadkowski L, Illing V, et al. Adult attachment, depression, and eating disorder symptoms: The mediating role of affect regulation strategies. Pers Individ Dif 2009; 47: 662-7.
[http://dx.doi.org/10.1016/j.paid.2009.06.006]
] health problems. The ECR displayed measurement invariance across a variety of clinical and non-clinical populations [51Alessandri G, Fagnani C, Di Gennaro G, et al. Measurement invariance of the experiences in close relationships questionnaire across different populations. Span J Psychol 2014; 17E22
[http://dx.doi.org/10.1017/sjp.2014.19] [PMID: 25012389]
], and been shown to provide a sufficiently reliable assessment of attachment style not only in healthy or mildly or moderately distressed individuals, but also in psychiatric inpatients, even those diagnosed with a psychotic disorder, except for the most severely impaired patients [52Picardi A, Martinotti G, Paci M, Simi C, Caroppo E. Reliability of self-reported attachment style in patients with severe psychopathology. J Pers Assess 2011; 93(5): 491-9.
[http://dx.doi.org/10.1080/00223891.2011.594128] [PMID: 21859289]
]. It is a self-report instrument consisting of 36 items, each scored on a seven-point scale. The ECR yields scores on two scales, called ‘Anxiety’ and ‘Avoidance’, each consisting of 18 items, some of which are reverse-keyed. Higher scores indicate greater insecurity. Individuals scoring high on Anxiety tend to be preoccupied with romantic relationships, to worry about being abandoned, to desire a high degree of closeness, and to ask the partner for more commitment. Individuals scoring high on Avoidance tend to maintain emotional distance and avoid intimacy, are uncomfortable depending on their partner, and are reluctant to ask for support. We used the validated Italian version of the instrument [53Picardi A, Bitetti D, Puddu P, Pasquini P. La scala “Experiences in Close Relationships”, un nuovo strumento per la valutazione dell’attaccamento negli adulti: traduzione, adattamento, e validazione della versione italiana. Riv Psichiatr 2000; 35: 114-20.]. In this study, the reliability of the ECR scales as measured by Cronbach’s Alpha coefficient was 0.86 and 0.85 for Anxiety and Avoidance, respectively.

Psychiatric diagnoses were made by trained clinicians using the Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I) [40First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition 2002 November; ]. Several studies provided evidence of the superior validity of this clinician-administered interview over routine clinical interviews [54Fennig S, Naisberg-Fennig S, Craig TJ, Tanenberg-Karant M, Bromet EJ. Comparison of clinical and research diagnoses of substance use disorders in a first-admission psychotic sample. American Journal of Addiction 1996; 540, 55Ramirez Basco M, Bostic JQ, Davies D, et al. Methods to improve diagnostic accuracy in a community mental health setting. Am J Psychiatry 2000; 157(10): 1599-605.
[http://dx.doi.org/10.1176/appi.ajp.157.10.1599] [PMID: 11007713]
].

Clinical severity was evaluated by means of the 24-item version of the BPRS [41Lukoff D, Nuechterlein KH, Ventura J. Manual for expanded Brief Psychiatric Rating Scale. Schizophr Bull 1986; 12: 594-602.], which is a clinician-rated instrument consisting of 24 items, scored on a 7-point severity scale. We used a validated Italian version, which has high reliability [56Roncone R, Ventura J, Impallomeni M, et al. Reliability of an Italian standardized and expanded Brief Psychiatric Rating Scale (BPRS 4.0) in raters with high vs. low clinical experience. Acta Psychiatr Scand 1999; 100(3): 229-36.
[http://dx.doi.org/10.1111/j.1600-0447.1999.tb10850.x] [PMID: 10493090]
] and is based on the BPRS manual of administration, with defined anchor points and detailed probe questions and rules for scoring [57Ventura J, Lukoff D, Nuechterlein KH, Liberman RP, Green M, Shaner A. Appendix 1: Brief Psychiatric Rating Scale (BPRS) expanded version (4.0) scales, anchor points and administration manual. Int J Methods Psychiatr Res 1993; 3: 227-44.]. The items are scored on a 7-point severity scale ranging from 1 to 7. Higher scores indicate greater severity of psychiatric symptoms.

The clinicians who administered the SCID-I and the BPRS received specific training in administering and scoring the instruments. They based their ratings on all sources of information available, including not only patients’ answers and clinical observation, but also referral notes, medical records, and reports by relatives and friends. The inter-rater reliability was assessed on several occasions during the study period. The reliability of the SCID-I as measured by the kappa coefficient was satisfactory as it ranged from .75 to .94 for the most common diagnoses (psychotic, mood, anxiety, and eating disorders). The mean inter-rater reliability of the BPRS as measured by the intraclass correlation coefficient was also satisfactory, as it ranged from .85 to .93.

2.3. Statistical Analysis

Given that the previous literature consistently suggested substantial differences in attachment security between depressed patients and non-psychiatric controls, it would be reasonable to expect a medium to large effect size. A sensitivity analysis using G-power software, version 3.1 [58Faul F, Erdfelder E, Lang A-G, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39(2): 175-91.
[http://dx.doi.org/10.3758/BF03193146] [PMID: 17695343]
] indicated that, given alpha of 0.05 and power (1-beta) of 0.80, a study with four groups and a total sample size of 84 would be able to detect an effect size of 0.37 with a fixed effects, omnibus, one-way ANOVA (noncentrality parameter lambda = 11.44; critical F = 2.71; numerator df = 3; denominator df = 80). Therefore, the study is sufficiently powered to detect moderate differences in ECR scores between groups.

All statistical analyses were performed using SPSS Statistics for Mac, Version 20 (IBM Corp., Armonk, NY, USA). All statistical tests were two-tailed, with alpha set at 0.05. Firstly, participant characteristics were summarized using appropriate descriptive statistics. Then, Pearson’s correlation coefficient was used to test for the association between continuous variables, and the Chi-square test or Fisher’s exact test and analysis of variance (ANOVA) were used as appropriate to test for differences between groups in categorical or continuous variables, respectively. In order to adjust for multiple comparisons in ANOVA, Tukey’s post-hoc test was used for pairwise comparisons between groups.

3. RESULTS

On the one hand, as a result of the matching procedure, there were no significant differences in age, marital status, educational level, and BPRS scores between the study groups.

Fig. (1)
Mean score on attachment-related anxiety and avoidance by group.


On the other hand, as illustrated in Fig. (1), ANOVA revealed several significant between-group differences in attachment dimensions. The omnibus ANOVA was highly significant for both attachment-related anxiety (F = 8.33, df = 3, 80) and attachment-related avoidance (F = 14.15, df = 3, 80). Tukey’s post hoc test revealed that both patients with bipolar depression and recurrent major depression scored significantly higher (p<0.001) on attachment-related avoidance (mean scores 67.8±13.0 and 64.7±14.6, respectively) than patients with epilepsy and non-clinical controls (mean scores 44.3±21.8 and 43.5±11.9, respectively). The effect size of these differences was high (Cohen’s d = 1.31 with 95% C.I. 0.36-2.25 for the comparison between bipolar disorder and epilepsy; 1.95 with 95% C.I. 0.91-2.98 between bipolar disorder and non-clinical controls; 1.10 with 95% C.I. 0.18-2.01 between major depressive disorder and epilepsy; 1.59 with 95% C.I. 0.61-2.57 between major depressive disorder and non-clinical controls). Also, Tukey’s post hoc test showed that patients with bipolar depression scored significantly higher on attachment-related anxiety (mean score 83.6±12.5) as compared with patients with recurrent major depression (mean score 67.9±14.8; p=0.02), patients with epilepsy (mean score 58.4±22.3; p<0.001) and non-clinical controls (mean score 62.6±18.7; p=0.001). The effect size of these differences was high, too (Cohen’s d = 1.14 with 95% C.I. 0.22-2.06 for the comparison between bipolar disorder and major depressive disorder; 1.39 with 95% C.I. 0.44-2.34 between bipolar disorder and epilepsy; 1.32 with 95% C.I. 0.37-2.26 between bipolar disorder and non-clinical controls). The patients with recurrent major depression displayed higher scores on attachment-related anxiety (mean score 67.9±14.8) than the non-psychiatric control groups (mean score 58.4±22.3 and 62.6±18.7 for patients with epilepsy and non-clinical participants, respectively); while these between-groups differences were in the expected direction, they were of moderate magnitude (Cohen’s d = 0.50 with 95% C.I. -0.36-1.37 for the comparison between major depressive disorder and epilepsy; 0.31 with 95% C.I. -0.54-1.17 between major depressive disorder and non-clinical controls) and did not reach statistical significance.

There were no significant differences in attachment-related anxiety and avoidance between patients with bipolar I and bipolar II disorder. Also, no significant association between attachment dimensions and age, sex, marital status, or education was found in any group, except the findings of higher attachment-related anxiety in women as compared with men in the epilepsy group. In both psychiatric groups, attachment dimensions were not significantly correlated either with global clinical severity as measured by the BPRS total score, or with the severity of depression as measured by relevant BPRS items, such as depression, anxiety, suicidality, and guilt (all p>0.10).

4. DISCUSSION

The theoretical links between attachment insecurity and depression were first formulated by Bowlby [14Loss, sadness and depression Bowlby J. Attachment and loss31980; ]. He suggested that the loss of attachment security in early life contributes to the development of depression in adulthood, because the loss of security promotes the formation of negative representations of self and the world. Loss of attachment security can result not only from the death of a primary caregiver, but also from repeated failures to establish a secure relationship with a caregiver. A child who, despite may attempts, is unable to create stable and secure relationships with caregivers, tends to develop a model of the self as unworthy and incompetent, as he or she is likely to feel powerless and helpless in trying to keep a neglectful parent present, or to gain support, love, and approval from an inconsistently responsive or rejecting parent. Also, a child who consistently receives the message from a parent that he or she is incapable of inspiring love or admiration tends to form a model of the self as unlovable and a complementary model of others as unloving [59Bretherton I. Attachment theory: Retrospect and prospect. Monogr Soc Res Child Dev 1985; 50: 3-35.
[http://dx.doi.org/10.2307/3333824]
].

Consistently with theoretical expectations, we found that patients with unipolar and bipolar depression were character- ised by higher levels of attachment insecurity as compared with non-psychiatric comparison groups. Among attachment dimen- sions, it was avoidance that mostly distinguished depressed patients from controls. On the one hand, both patients with bipolar depression and recurrent major depression displayed significantly higher scores on attachment-related avoidance than patients with epilepsy and non-clinical participants, with differences of large magnitude. On the other hand, the difference in attachment-related anxiety between patients with unipolar depression and the non-psychiatric control groups was moderate in magnitude and did not reach statistical signi- ficance. This finding is consistent with theoretical formulations suggesting that consistent rejection and neglect by the caregiver, which are the postulated antecedents of avoidant attachment, may lead a child to form an internal working model of himself or herself as not worthy of help and comfort [59Bretherton I. Attachment theory: Retrospect and prospect. Monogr Soc Res Child Dev 1985; 50: 3-35.
[http://dx.doi.org/10.2307/3333824]
], which would predispose to depression [60Guidano VF. Complexity of the self 1987.]. This finding is also in line with previous studies reporting that unipolar depression was associated more closely with dismissing states of mind about attachment [28Ivarsson T, Granqvist P, Gillberg C, Broberg AG. Attachment states of mind in adolescents with Obsessive-Compulsive Disorder and/or depressive disorders: a controlled study. Eur Child Adolesc Psychiatry 2010; 19(11): 845-53.
[http://dx.doi.org/10.1007/s00787-010-0120-x] [PMID: 20607573]
, 31Patrick M, Hobson RP, Castle D, Howard R, Maughan B. Personality disorder and the mental representation of early social experience. Dev Psychopathol 1994; 6: 375-88.
[http://dx.doi.org/10.1017/S0954579400004648]
] and that patients with bipolar disorder were more often characterised by an avoidant attachment style as compared with healthy controls [35Kökçü F, Kesebir S. [The relationship between attachment style, and temperament, personality and bipolar symptoms: a controlled study on bipolar patients and their children]. Turk Psikiyatr Derg 2010; 21(4): 309-18.
[PMID: 21125506]
]. However, the literature is not consistent regarding the type of insecurity that is more prevalent in depressed patients. Some studies using interview measures of attachment reported that depression was associated with preoccupied states of mind about attachment [26Fonagy P, Leigh T, Steele M, et al. The relation of attachment status, psychiatric classification, and response to psychotherapy. J Consult Clin Psychol 1996; 64(1): 22-31.
[http://dx.doi.org/10.1037/0022-006X.64.1.22] [PMID: 8907081]
, 34Rosenstein DS, Horowitz HA. Adolescent attachment and psychopathology. J Consult Clin Psychol 1996; 64(2): 244-53.
[http://dx.doi.org/10.1037/0022-006X.64.2.244] [PMID: 8871408]
]. Also, some of the studies using self-report instruments that allow distinguishing anxious from avoidant attachment features suggested that it is attachment anxiety that mostly characterises depression [30Myhr G, Sookman D, Pinard G. Attachment security and parental bonding in adults with obsessive-compulsive disorder: a comparison with depressed out-patients and healthy controls. Acta Psychiatr Scand 2004; 109(6): 447-56.
[http://dx.doi.org/10.1111/j.1600-0047.2004.00271.x] [PMID: 15117290]
, 32Pettem O, West M, Mahoney A, Keller A. Depression and attachment problems. J Psychiatry Neurosci 1993; 18(2): 78-81.
[PMID: 8461287]
], while others reported an increase in both anxiety and avoidance [29Marazziti D, Dell’osso B, Catena Dell’Osso M, et al. Romantic attachment in patients with mood and anxiety disorders. CNS Spectr 2007; 12(10): 751-6.
[http://dx.doi.org/10.1017/S1092852900015431] [PMID: 17934379]
, 33Reis S, Grenyer BF. Fear of intimacy in women: relationship between attachment styles and depressive symptoms. Psychopathology 2004; 37(6): 299-303.
[http://dx.doi.org/10.1159/000082268] [PMID: 15564790]
]. Differences between studies in design, assessment instrument, specific depressive disorder studied, psychiatric comorbidity, and predominance of externalising or internal- ising symptoms [23Stovall-McClough KC, Dozier M. Attachment states of mind and psychopathology in adulthood.Handbook of attachment: Theory, research, and clinical applications 3rd ed. 2015; 715-38.] may account for the discrepancies in findings.

This finding of higher attachment insecurity in depressed patients is unlikely to be explained by mood state, as depressive symptoms do not substantially affect ECR scores. In a study on non-clinical participants, ECR scores showed only a modest correlation with depressive symptoms [22Picardi A, Caroppo E, Toni A, Bitetti D, Di Maria G. Stability of attachment-related anxiety and avoidance and their relationships with the five-factor model and the psychobiological model of personality. Psychol Psychother 2005; 78(Pt 3): 327-45.
[http://dx.doi.org/10.1348/147608305X26882] [PMID: 16259850]
]. In a study on psychiatric inpatients, ECR scores did not significantly correlate with the severity of depressive symptoms at admission, and they showed high absolute and relative stability over a 2-month interval despite a substantial improvement in depressive symptoms during inpatient stay [52Picardi A, Martinotti G, Paci M, Simi C, Caroppo E. Reliability of self-reported attachment style in patients with severe psychopathology. J Pers Assess 2011; 93(5): 491-9.
[http://dx.doi.org/10.1080/00223891.2011.594128] [PMID: 21859289]
]. The finding of greater attachment insecurity in patients with depression is also unlikely to be explained by a sedative or antidepressant medication. Although the effect of psychotropic drugs on attachment measures has not been formally tested, if there is any effect it is likely in the direction of reducing perceived insecurity, which would actually attenuate the difference with non-psychiatric control groups. Our finding corroborates previous reports of greater attachment insecurity in patients with unipolar [24Armsden GC, McCauley E, Greenberg MT, Burke PM, Mitchell JR. Parent and peer attachment in early adolescent depression. J Abnorm Child Psychol 1990; 18(6): 683-97.
[http://dx.doi.org/10.1007/BF01342754] [PMID: 2074346]
, 27Fuhr K, Reitenbach I, Kraemer J, Hautzinger M, Meyer TD. Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders. J Affect Disord 2017; 212: 110-6.
[http://dx.doi.org/10.1016/j.jad.2017.01.021] [PMID: 28160683]
-30Myhr G, Sookman D, Pinard G. Attachment security and parental bonding in adults with obsessive-compulsive disorder: a comparison with depressed out-patients and healthy controls. Acta Psychiatr Scand 2004; 109(6): 447-56.
[http://dx.doi.org/10.1111/j.1600-0047.2004.00271.x] [PMID: 15117290]
, 32Pettem O, West M, Mahoney A, Keller A. Depression and attachment problems. J Psychiatry Neurosci 1993; 18(2): 78-81.
[PMID: 8461287]
, 33Reis S, Grenyer BF. Fear of intimacy in women: relationship between attachment styles and depressive symptoms. Psychopathology 2004; 37(6): 299-303.
[http://dx.doi.org/10.1159/000082268] [PMID: 15564790]
] and bipolar [27Fuhr K, Reitenbach I, Kraemer J, Hautzinger M, Meyer TD. Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders. J Affect Disord 2017; 212: 110-6.
[http://dx.doi.org/10.1016/j.jad.2017.01.021] [PMID: 28160683]
, 35Kökçü F, Kesebir S. [The relationship between attachment style, and temperament, personality and bipolar symptoms: a controlled study on bipolar patients and their children]. Turk Psikiyatr Derg 2010; 21(4): 309-18.
[PMID: 21125506]
-38Rosenfarb IS, Becker J, Khan A. Perceptions of parental and peer attachments by women with mood disorders. J Abnorm Psychol 1994; 103(4): 637-44.
[http://dx.doi.org/10.1037/0021-843X.103.4.637] [PMID: 7822564]
] depression as compared with healthy controls. The present study also extends previous findings by showing that attachment insecurity in depression is also higher than in a severe chronic neurological disease, such as drug-resistant epilepsy.

Attachment insecurity, in itself, is unlikely to be a sufficient cause of mood disorders. Other biological, psycho- logical, and socio-cultural factors are likely to complement or potentiate the effects of attachment experiences in the development of psychopathology [61Mikulincer M, Shaver PR. An attachment perspective on psychopathology. World Psychiatry 2012; 11(1): 11-5.
[http://dx.doi.org/10.1016/j.wpsyc.2012.01.003] [PMID: 22294997]
]. While keeping this in mind, research has started to reveal some pathways through which attachment insecurity can contribute to vulnerability to depression. The findings implicate a network of interrelated cognitive, coping, and interpersonal processes by which attachment insecurity may increase susceptibility to depression. Concerning cognitive processes, the negative attitudes rooted within the internal working models of insecurely attached individuals may negatively bias perceptions of the self and of close relationship partners [62Roberts JE, Gotlib IH, Kassel JD. Adult attachment security and symptoms of depression: the mediating roles of dysfunctional attitudes and low self-esteem. J Pers Soc Psychol 1996; 70(2): 310-20.
[http://dx.doi.org/10.1037/0022-3514.70.2.310] [PMID: 8636884]
]. Indeed, research suggests a mediating role for low self-esteem, low self-efficacy expec- tancies, threat appraisal, perceived lack of social support, maladaptive perfectionism, self-criticism, and hopelessness [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016., 27Fuhr K, Reitenbach I, Kraemer J, Hautzinger M, Meyer TD. Attachment, dysfunctional attitudes, self-esteem, and association to depressive symptoms in patients with mood disorders. J Affect Disord 2017; 212: 110-6.
[http://dx.doi.org/10.1016/j.jad.2017.01.021] [PMID: 28160683]
]. Regarding emotion regulation, attachment theory posits that secure individuals develop healthy emotion regulation skills through interactions with available caregivers. On the contrary, individuals with high attachment anxiety or avoidance tend to rely on emotion regulation strategies that amplify or suppress emotion, respectively. Research indeed indicates that difficulties in emotion regulation may contribute to the link between insecure attachment and mood disorders [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016., 63Malik S, Wells A, Wittkowski A. Emotion regulation as a mediator in the relationship between attachment and depressive symptomatology: A systematic review. J Affect Disord 2015; 172: 428-44.
[http://dx.doi.org/10.1016/j.jad.2014.10.007] [PMID: 25451448]
]. As far as interpersonal processes are concerned, the repeated failure to receive support from caregivers and the resulting reliance on insecure strategies based on the hyper-activation or deactivation of the attachment system hinder the acquisition of social skills and cause substantial problems in interpersonal relations. Indeed, research suggests that interpersonal difficulties, such as reduced emotional expressiveness, difficulties with assertiveness, excessive reassurance seeking, inability to meet closeness and autonomy needs, and feelings of loneliness, act as additional mediating paths between attachment insecurity and mood disorders [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.].

It has also been hypothesised that the decreased ability to feel soothed and safe with attachment figures that characterises insecure attachment may predispose individuals to an increased focus on and concern for social rank. Insecurely attached individuals may tend to rely more on social competition strategies than affiliative strategies in order to achieve a place in the social group that allows them to exercise control over social resources [64Gilbert P. Compassion and cruelty: Biopsychosocial approach. In: Gilbert P, Ed. Compassion: Conceptualisations, research and use in psychotherapy 2005; 9-74.]. The interaction between attachment and social rank systems might be particularly relevant in bipolar disorder, as mood variation was found to be linked to variation in social rank evaluations in patients with bipolar disorder [65Gilbert P, McEwan K, Hay J, Irons C, Cheung M. Social rank and attachment in people with a bipolar disorder. Clin Psychol Psychother 2007; 14: 48-53.
[http://dx.doi.org/10.1002/cpp.508]
], while mania proneness was found to be related to the pursuit of dominance and socially dominant behaviours [66Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.].

In this study, the group showing the highest level of attachment insecurity was the group of patients with bipolar depression. These patients displayed significantly higher scores on attachment-related avoidance than non-psychiatric controls, and showed significantly higher scores on attachment-related anxiety not only compared with non-psychiatric controls, but also with patients with unipolar depression. This finding suggests the presence, at least in some patients, of a fearfully avoidant attachment style. Fearful avoidance is characterised by high levels of both anxiety and avoidance and has some degree of overlap with the construct of disorganized attachment [67Shorey HS, Synder CR. The role of adult attachment styles in psychopathology and psychotherapy outcomes. Rev Gen Psychol 2006; 10: 1-20.
[http://dx.doi.org/10.1037/1089-2680.10.1.1]
, 68Simpson JA, Rholes WS. Fearful-avoidance, disorganization, and multiple working models: some directions for future theory and research. Attach Hum Dev 2002; 4(2): 223-9.
[http://dx.doi.org/10.1080/14616730210154207] [PMID: 12467516]
]. Theoretically, fearful avoidance derives from a failure to attain any of the objectives of the three main attachment strategies, i.e., protection and support resulting from proximity seeking, or intense and chronic activation of the attachment system until proximity is achieved, or defensive deactivation of the system. This can happen if a child is abused, or if he or she has a confused, drug-addicted, or grieving parent, whose behaviour cannot be predicted and who cannot be relied upon to provide comfort. In such cases, the attachment system is reactivated despite deactivating strategies, attachment-related needs and worries become simultaneously accessible, and the child gets trapped in a cycle of conflict-riddled attempts to meet personal needs while avoiding rejection or mishandling. Research indicates that fearfully avoidant individuals have especially negative representations of their romantic partners, are more likely than others to be involved in highly distressed and violent couple relationships, and have the poorest mental health [17Mikulincer M, Shaver PR. Attachment in adulthood: structure, dynamics, and change 2nd ed. 2016.]. Given their difficulty developing a coherent attachment strategy and the related severe deficits in emotion and behaviour regulation, these individuals may also experience rapid shifts between states of hyper-arousal and withdrawal, which may result in disorganisation of affects and associated behaviours [69Sarkar J, Adshead G. Personality disorders as disorganisation of attachment and affect regulation. Adv Psychiatr Treat 2006; 12: 297-305.
[http://dx.doi.org/10.1192/apt.12.4.297]
] and in the development of mood instability, thereby increasing their vulnerability to bipolar disorder. Childhood traumatic experiences, particularly emotional neglect, appear indeed to be significantly associated with bipolar disorder [70Watson S, Gallagher P, Dougall D, et al. Childhood trauma in bipolar disorder. Aust N Z J Psychiatry 2014; 48(6): 564-70.
[http://dx.doi.org/10.1177/0004867413516681] [PMID: 24343193]
]. Of note, childhood trauma may interact with a number of genes involved in a variety of biological pathways to decrease the age of onset of the disorder or increase suicide risk. Epigenetic molecular mechanisms may also play a role in the neurobiological effects of childhood trauma in bipolar disorder [71Aas M, Henry C, Andreassen OA, Bellivier F, Melle I, Etain B. The role of childhood trauma in bipolar disorders. Int J Bipolar Disord 2016; 4: 2.
[http://dx.doi.org/10.1186/s40345-015-0042-0]
].

Strong points of this study are the use of state-of-the-art instruments to establish a psychiatric diagnosis and measure adult attachment style, the inclusion of multiple clinical and non-clinical comparison groups, and the use of individual matching for demographic variables to control confounding. However, the study has also several limitations. Firstly, the sample size was relatively small, although the study was sufficiently powered to detect medium to large between-group differences. Secondly, the cross-sectional design precludes firm causal inferences regarding the nature of relationships between variables. Although there is evidence of moderate stability of individual differences in attachment security from infancy to adulthood [72Fraley RC. Attachment stability from infancy to adulthood: Metaanalysis and dynamic modeling of developmental mechanisms. Pers Soc Psychol Rev 2002; 6: 123-51.
[http://dx.doi.org/10.1207/S15327957PSPR0602_03]
, 73Grossmann KE, Grossmann K, Waters E, Eds. Attachment from infancy to adulthood: The major longitudinal studies 2005.], it cannot be stated with certainty that the high levels of insecurity that we observed in our patients were already present during childhood and predated the onset of their mood disorder. Thirdly, it cannot be ruled out that the insecurity displayed by our patients with mood disorders may at least partly follow from experiencing long-term illness. This limitation is inherent in the long-term nature of the disorders in question, as a substantial period of time is required before the diagnosis can be made. However, the inclusion of a comparison group consisting of patients suffering from a chronic illness in which depressive and anxiety symptoms are common [74Jackson MJ, Turkington D. Depression and anxiety in epilepsy. J Neurol Neurosurg Psychiatry 2005; 76(Suppl. 1): i45-7.
[http://dx.doi.org/10.1136/jnnp.2004.060467] [PMID: 15718221]
] should mitigate this limitation. Fourthly, we used a self-report measure to assess adult attachment. Despite being valid and reliable, self-report measures of romantic attachment cannot be considered identical to interview measures of the state of mind with regard to attachment experiences during childhood [75Roisman GI, Holland A, Fortuna K, Fraley RC, Clausell E, Clarke A. The Adult Attachment Interview and self-reports of attachment style: an empirical rapprochement. J Pers Soc Psychol 2007; 92(4): 678-97.
[http://dx.doi.org/10.1037/0022-3514.92.4.678] [PMID: 17469952]
]. Further studies are needed to extend our findings to interview measures of attachment. Fifthly, although no participant included in the non-psychiatric control groups was experiencing a major depressive episode, we cannot exclude that depressive symptoms were present to some degree in a number of these participants. However, this would not threaten the validity of our findings, as it would have had a conservative effect on the results. Sixthly, our findings may not generalise to patients with other forms of unipolar depression, such as single episode major depression or dysthymic disorder. Seventhly, some degree of selection bias may have occurred as attachment style may affect help-seeking behaviour, including the decision to seek treatment. A further limitation is that we relied on a single assessment; a follow-up evaluation would have been useful to confirm the results. Finally, we did not measure putative mediators of the association between insecure attachment and mood disorders, such as cognitive vulnerability factors, impaired emotion regulation, and interpersonal difficulties.

CONCLUSION

Although these limitations suggest a cautious interpretation of the results, they are consistent with previous studies and support Bowlby's hypothesis that attachment insecurity may predispose to depression [14Loss, sadness and depression Bowlby J. Attachment and loss31980; ]. Attachment theory also provides a valuable framework for guiding treatment. Authors from several different theoretical perspectives [76Byng-Hall J. Creating a secure family base: some implications of attachment theory for family therapy. Fam Process 1995; 34(1): 45-58.
[http://dx.doi.org/10.1111/j.1545-5300.1995.00045.x] [PMID: 7628600]
-81Holmes J, Slade A. Attachment in therapeutic practice 2018.] have delineated several ways in which attachment theory can help inform clinical practice and therapeutic interventions. These principles can be applied not only to psychotherapy for unipolar depression, but also to psychotherapeutic interven- tions for bipolar disorder involving both patients and their relatives, such as family-focused treatment [82Miklowitz DJ, Biuckians A, Richards JA. Early-onset bipolar disorder: a family treatment perspective. Dev Psychopathol 2006; 18(4): 1247-65.
[http://dx.doi.org/10.1017/S0954579406060603] [PMID: 17064437]
] and cognitive-psychoeducational group interventions [83Bernhard B, Schaub A, Kümmler P, et al. Impact of cognitive-psychoeducational interventions in bipolar patients and their relatives. Eur Psychiatry 2006; 21(2): 81-6.
[http://dx.doi.org/10.1016/j.eurpsy.2005.09.007] [PMID: 16380236]
]. Interventions specifically addressing the attachment and affiliative systems in patients with bipolar disorder are also being developed [84Lowens I. Compassion Focused Therapy for People with Bipolar Disorder. Int J Cogn Ther 2010; 3: 172-85.
[http://dx.doi.org/10.1521/ijct.2010.3.2.172]
]. Also, attachment theory provides a helpful framework for informing the design and delivery of general mental health services in order to meet users’ attachment needs [85Bucci S, Roberts NH, Danquah AN, Berry K. Using attachment theory to inform the design and delivery of mental health services: a systematic review of the literature. Psychol Psychother 2015; 88(1): 1-20.
[http://dx.doi.org/10.1111/papt.12029] [PMID: 24729543]
]. In the field of mood disorders, research based on attachment theory is still relatively scarce, and several important issues need to be addressed. Firstly, longitudinal studies are needed to confirm the role of attachment insecurity as a risk factor for mood disorders. Secondly, more research is necessary on the relationship between specific attachment dimensions and patterns and different forms of mood disorders. Thirdly, there is a need for controlled clinical trials examining the effectiveness of attachment-informed interventions in improving the outcome for patients with mood disorders. Finally, future studies should investigate the interaction between insecure attachment and other risk factors, including both genetic and environmental influences.

ETHICS APPROVAL AND CONSENT TO PARTICIPATE

The study was carried out in accordance with the ethical code of conduct of the Italian National Institute of Health.

HUMAN AND ANIMAL RIGHTS

No animals were used in this study. The study protocols were followed in accordance with the international ethical guidlines for biomedical research involving human subjects and the declaration of helsinki.

CONSENT FOR PUBLICATION

Written and informed consent was obtained from all the participants.

AVAILABILITY OF DATA AND MATERIAL

The study dataset cannot be placed in a public repository as this would violate the Italian privacy law, even if the data were anonymized. Interested researchers may request the data to the corresponding author.

FUNDING

None.

CONFLICT OF INTEREST

The authors declare no conflict of interest, financial or otherwise.

ACKNOWLEDGEMENTS

Declared none.

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