Table 2: Clinical Characteristics of 301 Patients with First Episode Depression, Totally and by Age-of-Onset

Characteristic Total (N=301) Age ≤ 30 Years (N=99) Age > 30 Years (N=202) P 1 B /OR (95% CI)2 Early vs Late Onset (Adjusted for Gender) P 3

Severity of depression4, N (%)
Mild 73 (24.3) 19 (19.2) 54 (26.7) 0.6 (0.3-1.2) 0.1
Moderate 161 (53.5 56 (56.6) 105 (52.0) 0.4 0.8 (0.4-1.5) 0.5
Severe 67 (22.3) 24 (24.2) 43 (21.3) 1

Melancholic features4, N (%) 196 (65.1) 58 (58.6) 138 (68.3) 0.1 0.7 (0.4-1.2) 0.2

Psychotic features4, N (%) 13 (4.3) 4 (4.0) 9 (4.5) 0.9 1.4 (0.4-5.0) 0.6

Suicidal ideations4, N (%) 194 (64.5) 69 (69.7) 125 (61.9) 0.2 1.6 (0.9-2.7) 0.09

Atypical features4, N (%) 11 (3.7) 10 (10.1) 1 (0.5) <0.0005 15.4 (1.9-122.9) 0.01

Psychiatric co-morbidity4, N (%)
Anxiety/OCD 143 (47.5) 53 (53.5) 90 (44.6) 0.1 1.2 (0.7-2.0) 0.4
Alcohol abuse 45 (15.0) 7 (7.1) 38 (18.8) 0.007 0.4 (0.2-0.9) 0.03
Drug abuse 22 (7.3) 14 (14.1) 8 (4.0) 0.001 4.1 (1.6-10.8) 0.004
Somatoform/eating disorders 14 (4.7) 8 (8.1) 6 (3.0) 0.05 2.1 (0.7-6.4) 0.2

Personality disorders5, N (%)
Any personality disorder
Cluster A
Paranoid 96 (31.9) 55 (55.6) 41 (20.3) <0.0005 4.8 (2.8-8.3) <0.0005
Schizotypal 3 (1.0) 2 (2.0) 1 (0.5) 0.2 2.8 (0.2-31.1) 0.4
Schizoid 3 (1.0) 2 (2.0) 1 (0.5) 0.2 8.2 (0.7-105.7) 0.1
Cluster B 3 (1.0) 2 (2.0) 1 (0.5) 0.2 4.8 (0.4-62.1) 0.2
Antisocial 9 (3.0) 5 (5.1) 4 (2.0) 0.1 3.5 (0.1-1.8) 0.09
Borderline 35 (11.6) 26 (26.3) 9 (4.5) <0.0005 6.2 (2.7-14.2) <0.0005
Histrionic 0 0 0 - - -
Narcissisitic 1 (0.3) 0 1 (0.5) 0.5 - -
Cluster C 30 (10.0) 14 (14.1) 16 (7.9) 0.09 1.6 (0.7-3.4) 0.3
Evasive 12 (4.) 9 (9.1) 3 (1.5) 0.002 9.8 (2.3-41.0) 0.002
Dependent 19 (6.3) 10 (10.1) 9 (4.5) 0.06 3.4 (1.2-9.4) 0.02
Obsessive-compulsive 26 (8.6) 14 (14.1) 12 (5.9) 0.02 2.0 (0.9-4.7) 0.1
Depressive

Personality traits6, mean (SD)
Neuroticism-score 11.6 (6.3) 14.0 (5.5) 10.5 (6.3) <0.0005 -2.7 (-4.4- -1.0) 0.002
Extroversion-score 11.5 (5.4) 11.4 (5.7) 11.5 (5.3) 0.9 -0.05 (-1.6-1.5) 1.0

Anxiety score7, mean (SD) 10.2 (6.2) 10.7 (5.7) 10.0 (6.4) 0.4 0.1 (-1.4-1.7) 0.9

Family history of psychiatric illness in 1. generation, N (%)
Depression 87 (28.9) 33 (33.3) 54 (26.7) 0.2 1.4 (0.8-2.5) 0.20
Any psychiatric illness 199 (66.1) 67 (67.7) 132 (65.3) 0.7 1.0 (0.6-1.6) 0.9

Family history of suicide in 1. generation, N (%) 10 (3.3) 2 (2.0) 8 (4.0) 0.4 0.5 (0.1-2.3) 0.3

One or more stressful life events8, N (%) 189 (62.8) 46 (46.5) 143 (70.8) <0.0005 0.4 (0.2-0.7) 0.001

1 P-values (2-sided) in univariate analyses comparing patients with early and late onset (χ2-test categorical data and t-test for continuous data).
2 Correlation coefficients in multiple regression models / odds-ratios in logistic regression models; the effect of age-of-onset adjusted for the affect of gender.
3 P-values (2-sided) in the regression models.
4 According to Schedules for Clinical Assessment in Neuropsychiatry (SCAN).
5 According to The Structured Clinical Interview for DSM-IV Axis II Personality Disorders (SCID-II).
6 According to Eysenck Personality Questionnaire (EPQ).
7 According to Symptom Rating Scale for Depression and Anxiety, Anxiety Subscale.
8 According to Interview of Recent Life Events (IRLE).