Table 2: Clinical Trials of Depression Therapy in Patients with Cardiac Diseases

Trial	Therapies	Treatment Period	Results
M-HART [57]	Home nursing intervention [vs usual care] for psychological distress	1 year	Prognosis: no improvement compared with usual care
Roose and colleagues [58] and Nelson and colleagues [59]	Nortriptyline vs paroxetine	6 weeks	Depression: both effective Drug safety: nortriptyline toxic
ENRICHD [60]	Cognitive behavior therapy vs usual medical care	11 sessions over 6 months	Depression: cognitive behavior therapy modestly effective Prognosis: no difference vs usual care
SADHART [61]	Sertraline vs placebo	24 weeks	Depression: effective vs placebo Safety: safe
MIND-IT [62]	Mirtazapine vs placebo	24 weeks	Depression: no difference vs placebo Prognosis: no difference vs placebo
CREATE [63]	Citalopram ± Interpersonal psychotherapy	12 weeks	Depression: citalopram effective; interpersonal psychotherapy not effective