Inhibition of Renal Fibrosis and Glomerular Injury by Sacubitril/Valsartan, a Combination Angiotensin Receptor Blocker and Neprilysin Inhibitor, in a Salt-Sensitive Hypertensive Model Using Angiotensin 1 Receptor Knockout Mice: The Contribution of Non-Angiotensin Blocking Effects to Renal Protection

Fig. (2) % Renal tubule fibrosis. We compared renal tubule fibrosis as evaluated by Sirius red staining. After the treatment with aldosterone and 1 % NaCl, % renal tubule fibrosis is significantly increased (p < 0.05), and Sac/Val (low and high dose) significantly decreases % renal tubule fibrosis compared to valsartan (low and high dose) (p < 0.05). NT, non-treatment; CON, Control; Val, Valsartan; Sac/Val, Sacubitril/Valsartan.