Inhibition of Renal Fibrosis and Glomerular Injury by Sacubitril/Valsartan, a Combination Angiotensin Receptor Blocker and Neprilysin Inhibitor, in a Salt-Sensitive Hypertensive Model Using Angiotensin 1 Receptor Knockout Mice: The Contribution of Non-Angiotensin Blocking Effects to Renal Protection

Fig. (4) Glomerular injury. We compared glomerular injury as evaluated by PAS staining. After the treatment with aldosterone and 1% NaCl, the glomerular injury score is significantly increased (p < 0.05), and Sac/Val; Sacubitril/Valsartan (low and high dose) significantly decreases the score compared to valsartan (low and high dose) (p<0.05). NT, non-treatment; CON, Control; Val, Valsartan; Sac/Val, Sacubitril/Valsartan.