-	Case 1	Case 2	Case 3	Case 4
Age/Gender	46/M	26/ F	35/F	33/F
SLE diagnosis (year)	2008	2007	1998	1999
Onset of CIDP post SLE Diagnosis (months)	8 months	8 months	7 years	13 years
CIDP symptoms	Bilateral quadriceps weakness, normal sensation, normal reflexes	Numbness of right upper limb with loss sensation, light touch and pinprick (C6-T1) and absent reflexes	Bilateral intermittent upper limb numbness with progressive bilateral lower limb weakness.	Neuropathic pain affecting all 4 limbs, with reduced power in both limbs with hyperreflexia
Durations of symptoms	2 weeks	3 weeks	One year	2 weeks
EMG/MRI findings	LP: elevated protein, no oligoclonal bands MRI Brain and Spine: normal NCS: axonal and sensory polyneuropathy	LP: elevated protein MRI Spine: normal NCS: normal	LP: elevated protein, no oligoclonal bands MRI Brain: normal MRI Spine: transverse myelitis hyper intense lesion C3-T2	LP: normal, no oligoclonal bands MRI Spine: hyper intense lesion C5-C7 with cord oedema
Concomitant manifestations	LN Class IV	MSK LN Class IV	Cerebral lupus MSK LN Class III	MSK LN III/V
Antibodies (at diagnosis) C3(NR:86-185 mg/dL) C4(NR:20-59 mg/dL)	C3 69.2 mg/dL C4 21.7mg/dL ANA 1:640 Anti dsDNA negative ACL negative	C3 24.5 mg/dL C4 < 10 mg/dL ANA 1:320 Anti dsDNA positive ACL negative	C3 49.6 mg/dL C4 < 10 mg/dL ANA 1:160 Anti dsDNA negative ACL negative	C3 99.2 mg/dL C4 14.1 mg/dL ANA 1:160 Anti dsDNA positive ACL negative
Treatment	Corticosteroids, Mycophenolate mofetil, gabapentin	Corticosteroids, Plasmapheresis, IV Immunglobulin IV Cyclophosphamide for one year then maintained with mycophenolate mofetil and ciclosporin A	Corticosteroids, Plasmapheresis, IV Immunoglobulin, IV cyclophosphamide then maintained with mycophenolate mofetil	Corticosteroids, IV cyclophosphamide then maintained with myfortic and tacrolimus
Outcome	Symptoms resolved gradually over one year	Relapsed with new onset of numbness & reduced sensation in T4 -T10 dermatomes whilst on treatment with IV cyclophosphamide for 18 months Six months later symptoms recurred and repeat MRI demonstrated transverse myelitis C1-C7 Persistent numbness despite SLE being in complete remission but ADL independent	Relapsed 8 years later with generalized tonic clonic seizures and bilateral numbness and weakness of both limbs with hyperreflexia. MRI Brain and Spine: hyperintense C3- T3 lesions Treated as relapsed CNS lupus with IV cyclophosphamide Symptoms persist but ADL independent	Symptoms improved gradually over 6 months
Follow up (years)	8 years	7 years	18 years	17 years