|Scientist Conducted Study||Part of Curcuma Longa Plant Used||
Study Conducted on
|Study Conducted on Human||
|Models||Type of Study||Conclusion||Inference|
|Ashish Shubhas et al.(2013) ||Curcuminoids and oil free aqueous extract of C. longa
|Albino swiss Mice and Albino Wistar rats||NA||NA||Xylene induced ear edema and cotton pallet granuloma model||Comparative.||COFAE at dose level (p< 0.05) reduce inflammation in each animal model. On comparative study the oil free aqueous extract showed better anti-inflammatory effect as compared to curcuminoids.||The active constituents of curcumin has potent anti-inflammatory effect in its different forms.|
|Chang et al.
|8000 mg curcumin
|NA||25 subjects||Phase I||NA||NA||The study showed that curcumin is not toxic to humans when administered for 3 months up to the dose of 8,000 mg/day (orally).||Curcumin is nontoxic to human.|
|Satoskar et al.(1986) ||Curcumin (1200 mg/d) and phenylbutazone (300mg/d)||NA||45 subjects||NA||NA||Comparative
|Controlled trial study was conducted
45 postsurgical patients divided into groups
placebo, curcumin (1200 mg/d), and
phenylbutazone (300 mg/d). Phenylbutazone and curcumin showed better anti-inflammatory effect.
|Curcumin showed better anti-inflammatory effect.|
|Bundy Rafe et al. (2004) ||1 tablet of curcumin extract per 8th day||NA||500 IBS
(screened for study)
|Phase II||NA||Partially blinded, randomized, two-dose, pilot study.||The prevalence rate of inflammatory bowel syndrome found to be declined up to 41% and 57% and further the percentage declined to 53%-60% between base line after treatment in both groups.||The anti-inflammatory effect of curcumin has been seen in inflammatory bowel syndrome.|
|Chandran Binu et al.
|Curcumin (500 mg) and Diclofenac Sodium (50 mg)||NA||45||Phase II||NA||Randomized, single-blinded, pilot study.||Patients were randomly allocated in 1:1:1 ratio for administration of curcumin 500 mg (Group I) or curcumin 500 mg + diclofenac sodium 50 mg (Group II), or diclofenac sodium 50 mg (Group III) over a period of 8 weeks.||Curcumin showed better anti-inflammatory effect and reduced pain also.|