Preparation and Evaluation of Multi-Particulate System (Pellets) of Prasugrel Hydrochloride

Table 2: Prasugrel release kinetics from selected batches.

Kinetic model	Zero order D_t = D₀ + K₀t		First order ln D_t = ln D₀ + K₁t		Higuchi D_t = D₀ + K_Ht^1/2		Korsemeyer-Peppas D_t/D_∞ = K_P tⁿ
Batch	R²	K₀	R²	K₁	R²	K_H	R²	K_P	n
F	0.61	3.43	0.94	0.139	0.89	20.3	0.98	0.38	0.28
G	0.74	3.66	0.96	0.127	0.94	20.02	0.97	0.45	0.22

where D_tis the amount of drug released at time t, D₀ is the initial amount of drug released, D_t/D_∞ is fraction of drug released at time t, k₀ is the zero-order release constant, k₁ is the first-order release constant, k_H is the Higuchi release constant, K_P is the Peppas release constant, and n is the release exponent.