Table 3: Evaluation of CNS depressant activity using actophotometer after 30 min.

Code Mean change in locomotor activity Mean ± SEM) % inhibition in locomotor activity
I II III I II III
4a 73±6.221* 59.4±13.422** 25.6±1.965*** 50 70.60 77.73
4b  73±8.626** 87.6±4.434* 24.4±1.939*** 68.52 38.08 78.78
4c 41.2±5.490*** 89.6±5.240* 98.2±2.354ns 64.17 22.08 14.60
4d 78.4±12.205** 102.8±3.397ns 23.4±0.8602*** 31.82 10.60 79.65
4e 71±10.232*** 64±4.517*** 54.6±2.561*** 38.78 44.34 52.52
4f 72.4±8.880** 65.8±5.054*** 56.6±3.473*** 37.04 42.78 50.78
4g 103.4±2.421ns 67.8±5.791*** 68.4±4.686** 10.08 41.04 40.52
4h 113.4±4.118ns 80±3.536*** 60.4±5.483*** 10.09 30.43 47.47
4i 97.6±7.891ns 83.8±7.723* 63±7.987*** 15.13 27.13 45.21
4j 102.4±8.964ns 93±4.087ns 38.8±4.883*** 10.95 19.13 66.26
4k 106.8±4.883ns 109.2±6.530ns 37.2±4.224** 7.13 5.04 67.65
4l 91.4±22.879ns 74.4±7.089ns 94.2±5.652ns 37.91 35.30 18.08
4m 76.2±3.839*** 115.8±3.967ns 90.2±4.893* 33.73 1.73 21.56
4n 143.2±17.362ns 74.4±3.415* 37.4±2.502*** 45.43 35.30 67.47
4o 76.8±4.341*** 112.4±4.297ns 92±4.889* 33.21 2.26 20
D 30.2±2.922 47
C 115±7.791

Each value represents the mean_SEM significantly different from the control at P<0.05; ns denotes not significant at P<0.05(Student’s t-test); *P<0.05, **P<0.01, ***P>0.05 locomotor activity score was measured for 10 min. D= Diazepam; C=control; I=30 mg/kg, II=100 mg/kg, III=300 mg/kg.