Table 4: Evaluation of CNS depressant activity using actophotometer after 4 h.

Code Mean change in locomotor activity (Mean ± SEM) % inhibition in locomotor activity
I II III I II III
4a 40±9.965*** 33.8±1.655*** 26±2.168*** 46.14 54.50 44.21
4b 75.2±11.608* 46.8±5.324*** 54.8±10.017*** 39.54 62.37 55.94
4c 36.8±6.094*** 58.2±5.161*** 64±4.231*** 39.53 43.56 42.28
4d 84±7.817* 138.2±4.432ns 19±1.414*** 32.47 11.09 43.24
4e 133±13.657ns 98±3.347ns 51.8±12.212*** 6.91 21.22 58.36
4f 116.8±6.248ns 82.4±5.115ns 120.2±10.288** 9.32 33.76 3.49
4g 99.2±3.839* 77.4±5.662*** 63.4±5.605*** 20.25 37.78 49.03
4h 114.2±6.053ns 99.8±2.922* 71.8±3.089*** 8.19 19.77 42.28
4i 93±9.354ns 78.8±9.452* 74.6±11.365** 25.24 36.65 40.03
4j 73.4±2.619*** 93.4±5.335* 42±8.620*** 40.99 24.91 66.23
4k 45±8.444*** 93.4±9.903* 28±2.713*** 43.56 24.91 38.90
4l 182±9.706ns 128.2±2.375ns 134.8±9.431ns 4.6 3.53 8.36
4m 87.8±10.758* 73.6±7.891** 52.4±8.035*** 29.42 40.83 57.87
4n 42.6±1.364*** 34.2±1.020*** 24.6±2.561*** 45.17 41.63 43.89
4o 97.6±6.645ns 80.2±5.229** 118.8±11.795ns 35.53 21.54 4.50
D 75±11.150 47.42
C 124.4±5.758

Each value represents the mean_SEM significantly different from the control at P<0.05; ns denotes not significant at P<0.05(Student’s t-test); *P<0.05, **P<0.01, ***P>0.05 locomotor activity score was measured for 10 min. D= Diazepam; C=control; I=30 mg/kg, II=100 mg/kg, III=300 mg/kg.