Microwave Assisted Facile Synthesis and Biological Evaluation of Novel 2-Indolyl -1, 5-Benzothiazepines

Table 5: Anticonvulsant screening of compounds.

Compounds	MES screen		Sc PTZ
Compounds	0.5 h	4 h	0.5 h	4 h
4a	100	300	100	300
4b	300	300	100	300
4c	300	300	---	---
4d	----	30	---	---
4e	100	300	---	---
4f	100	100	---	---
4g	30	300	300
4h	300	300	300	300
4i	300	300	300	300
4j	---	300	---	---
4k	---	100	100	300
4l	--	30	---	---
4m	---	100	---	---
4n	300	300	300	300
4o	--	300	---	---
Phenytoin	30	30	x	x

a Doses of 30, 100 and 300 mg/kg of the compound were administered and the protection measured after 0.5 and 4 h. The figures indicate the minimal dose required to cause protection in 50% or more of the animals. The dash (---) indicates the absence of anticonvulsant activity. x denotes not tested.