Design, Synthesis and Evaluation of Substituted 3-(1, 4-Diazepanyl)-Methyl-Phenyl-Sulphonamides as Potent 5-HT6 Antagonists in Cognitive Disorders

Table 1: Statistical values for 3D-QSAR model generated by PLS.

Training set	Test set
m = 6	-
n = 33	n_T = 13
R² = 0.98	Q² = 0.67
SD = 0.14	RMSE = 0.38
F = 281.50	Pearson-R = 0.83
P = 2.28e-22	-

m = number of PLS factors in the model; n = number of molecules in the training set; nT = number of molecules in test set; R² = coefficient of determination; Q² = R² for test set; SD = standard deviation of regression; RMSE = root-mean squared error; F = variance ratio; P = statistical significance; Pearson-R = Pearson correlation coefficient.