Design, Synthesis and Evaluation of Substituted 3-(1, 4-Diazepanyl)-Methyl-Phenyl-Sulphonamides as Potent 5-HT6 Antagonists in Cognitive Disorders

Table 4: Effect of Test compounds on Transfer latency in Elevated plus maze and Step down latency in Passive avoidance paradigm models in mice.

Groups	EPM (TL in seconds) n=6	PAP (SDL in seconds) n=6
Vehicle	38±1.91	177±3.31
Toxicant (Scopolamine) 0.4 mg/kg	58.16±1.34	146±6.831
Standard (Piracetam) 200 mg/kg + Scopolamine	38.66^a,g±1.37	201.16^a,g±6.44
Test 10f 10 mg/kg + Scopolamine	41.83^a,e,g,k±1.34	187.6667^a,g±12.93
Test 10f 30mg/kg + Scopolamine	41.83^a,e,g,k±1.34	187^a,g±14.88

The values are expressed as mean ± SD, where n=6 .^a P<0.001,^b P<0.01,^c P<0.05 as compared to toxicant control ; ^d P<0.001, ^e P<0.01,^f P<0.05 as compared to test A by using one way ANOVA followed by Turkey test. ^g P<0.001,^h P<0.01,ⁱ P<0.05 as compared to toxicant control ; ^j P<0.001, ^k P<0.01,^l P<0.05 as compared to test A by using one way ANOVA followed by Boneferroni test.