Design, Synthesis and Evaluation of Substituted 3-(1, 4-Diazepanyl)-Methyl-Phenyl-Sulphonamides as Potent 5-HT6 Antagonists in Cognitive Disorders

Table 5: Effect of Test compound on Acetyl cholinesterase level in Elevated plus maze and Passive avoidance paradigm models in mice.

Groups	EPM(AchE in nmole/min/g tissue) n=3	PAP (AchE in nmole/min/g tissue) n=3
Vehicle	207.98±4.58	212.5333±3.29
Toxicant (Scopolamine) 0.4 mg/kg	365.65±9.26	367.13±11.62
Standard (Piracetam) 200 mg/kg + Scopolamine	199.08^a,g±9.77	196.98^a,g±6.61
Test 10f 10 mg/kg + Scopolamine	223.34^a,g±14.17	217.79^a,g±4.50
Test 10f 30mg/kg + Scopolamine	223.52^a,g±9.92	221.91^a,g±14.44

The values are expressed as mean ± SD, where n=6 .^a P<0.001,^b P<0.01,^c P<0.05 as compared to toxicant control ; ^d P<0.001, ^e P<0.01,^f P<0.05 as compared to test A by using one way ANOVA followed by Turkey test. ^g P<0.001,^h P<0.01,ⁱ P<0.05 as compared to toxicant control ; ^j P<0.001, ^k P<0.01,^l P<0.05 as compared to test A by using one way ANOVA followed by Boneferroni test.