Table 3: Studies in Microspheres prepared by solvent evaporation technique.

Drug	Polymer	Result and Inferences	References
rhVEGF (human vascular endothelial growth factor)	Poly(lactic-co-glycolic acid); PLGA	Sustained order release of VEGF was observed for 2 weeks. Dynamic light scattering (DLS) showed monodispersed microparticles of small variation in micro particle size (<2%).	[36, 37]
Etoposide	Poly (ε-caprolactone)	Sustained microsphere with narrow size distribution and smooth surface.	[38]
Aspirin	Ethyl cellulose (EC), cellulose acetate phthalate (CAP) and their mixture (1:1)	Free flowing microspheres were observed. EC showed slower release rate than CAP and mixture.	[39]
Atenolol	Ethyl cellulose	Effect of various factors on release and entrapment was studied.	[40]
Theophylline	Cellulose acetate	Good yield (87.5%) and good entrapment efficiency (92.4%) was observed.	[41]
Telmisartan	Ethylcellulose	Hollow microsphere formation.	[42]
Nifedipine	Eudragit RL100	High drug-loading percent, successful retarding release (over 12 hours) and spherical and smooth surface morphology were obtained.	[43]
Salbutamol sulphate	HPMC and Carbopol	Good entrapment efficiency was observed (68.3±0.01 and 94.9±0.02%).	[44]
ValacyclovirHCl	Ethyl Cellulose	Floating microsphere could be obtained which will have high resident time in the upper part of GIT resulting in improved absorption.	[45]
Captopril	Eudragit S100, Ethyl Cellulose	A sustained release was obtained.	[46]
Stavudine	Ethylcellulose, Dibutylpthalate	Controlled release was obtained for a drug with very short half life.	[47]
Boswellic acid	HPMC, Ethylcellulose	Increased gastric retention	[48]
Ranitidine	HPMC K100, Xanthan gum, Eudragit S100	Using acrylic and hydrophilic polymer, gastric residence time can be increased.	[49]
Rosiglitazone maleate	HPMC, Ethylcellulose]	Decrease in gastric irritation, protection from gastric degradation	[50]
Cephalexin	Ethylcellulose	Sustained effect	[51]
Famotidine	Acrylocoat S100, cellulose acetate	The floating behavior, release rate and physical properties are affected.	[52]
Cefpodoximeproxetil	HPMC K100 M, Ethylcellulose	Sustained effect	[53]
Rabeprazol sodium	HPMC, Methyl cellulose	Improved short half life and prevention of degradation of drug from lower part of stomach	[54]
Clarithromycin	HPMC 15M, K4M, 100LV, Ethylcellulose	Sustained effect	[55]
Cimetidine	HPMC, Ethylcellulose	Sustained effect	[56]