Anticonvulsant Activities of 4-benzylidene-6-(4-methyl-phenyl)-4,5-dihydropyridazin-(2H)-ones and 4-benzylidene-6-(4-chloro-phenyl)-4,5-dihydropyridazin-(2H)-ones

Table 1: ACA of 6-(4-Chloro/4-methyl/3-nitro-Phenyl)-4-arylidene-4,5-dihydro pyridazin-3(2H)-ones (3a-m) against MES-induced convulsions.

S. No.	Groups	Flexion (sec)	Extensor (sec)	Clonus (sec)	Stupor (sec)	Recovery (%)
1	Control	3.34 ± 0.125	15.76±01.11	6.76 ± 01.11	48.90±07.65	60
2	PHT Sod	1.44 ± 0.051^a	0.00 ±0.00^a	1.84 ±0.23	7.78 ±0.58^a	100
3	Sod VPA	3.24±0.82	5.36±0.68	7.59±1.24	46.43±2.43	80
4	Compd3a	2.0±0.12^aγ	6.26±1.45^aγ	3.62±1.12^aγ	20.20±3.50^aγ	80
5	Compd3b	2.11±0.09^aγ	7.21±1.63^aγ	4.24±1.42^bγ	18.32±3.48^aγ	80
6	Compd3c	2.21±0.40^aγ	6.63±1.72^aγ	3.88±1.64^aγ	18.50±2.34^aγ	100
7	Compd3d	1.92±0.28^aγ	6.24±0.54^aγ	4.12±2.12^bγ	16.64±1.90^aγ	100
8	Compd3e	1.84±0.36^aγ	6.10±1.16^aγ	3.92±2.14^aγ	15.40±3.20^aγ	100
9	Compd3f	2.22±0.28^aγ	7.86±0.76^aγ	4.21±1.66^bγ	22.40±4.45^aγ	80
10	Compd3g	2.41±0.12^aγ	9.66±1.02^aγ	3.98±2.26^aγ	20.50±3.60^aγ	80
11	Compd3h	2.32±0.34^aγ	8.26±0.82^aγ	4.43±2.0^bγ	21.33±4.82^aγ	80
12	Compd3i	2.36±0.16^aγ	8.84±0.68^aγ	4.82±2.86^bγ	19.34±2.86^aγ	80
13	Compd3j	2.10±0.76^aγ	7.64±0.922^aγ	4.64±3.23^bγ	22.56±3.94^aγ	80

Control group: 0.5% CMC in distilled water; Standard drug: PHT sodium (25mg/kg); Test compounds: (50 mg/kg); n= 5, no. of animals in a group; ^aP< 0.001, ^bP< 0.01, when compared to control group and γ< 0.001, when compare with standard group.