Water Soluble Chitosan Mediated Voriconazole Microemulsion as Sustained Carrier for Ophthalmic Application: In vitro/Ex vivo/In vivo Evaluations

Table 1: Compositions of the selected voriconazole microemulsions.

Phase diagram	Batch code	VCZ (% w/v)	Modified chitosan (% w/v)	Oils (% w/w)			S_mix (% w/w) T80: PG		Water (% w/w)
Phase diagram	Batch code	VCZ (% w/v)	Modified chitosan (% w/v)	OA	IPM	IPP	1:1	2: 1	Water (% w/w)
A	OAVM-1	0.1	0.25	5	-	-	50	-	45
	OAVM-2	0.1	0.25	5	-	-	55	-	40
	OAVM-3	0.1	0.25	5	-	-	60	-	35
B	OAVM-4	0.1	0.25	5	-	-	-	45	50
	OAVM-5	0.1	0.25	5	-	-	-	50	45
	OAVM-6	0.1	0.25	5	-	-	-	55	40
C	IPMVM-7	0.1	0.25	-	5	-	35	-	60
	IPMVM-8	0.1	0.25	-	5	-	40	-	55
	IPMVM-9	0.1	0.25	-	5	-	45	-	50
D	IPMVM-10	0.1	0.25	-	5	-	-	35	60
	IPMVM-11	0.1	0.25	-	5	-	-	40	55
	IPMVM-12	0.1	0.25	-	5	-	-	45	50
E	IPPVM-13	0.1	0.25	-	-	5	35	-	60
	IPPVM-14	0.1	0.25	-	-	5	40	-	55
	IPPVM-15	0.1	0.25	-	-	5	45	-	50
F	IPPVM-16	0.1	0.25	-	-	5	-	35	60
	IPPVM-17	0.1	0.25	-	-	5	-	40	55
	IPPVM-18	0.1	0.25	-	-	5	-	45	50