Table 3: Physicochemical properties of voriconazole microemulsions (mean ± SD, n=3).

Batch code Droplet size (nm) Zeta potential
(mV)
PDI Drug content (%) Viscosity (cP) pH Conductivity (µS)
*OAVM-1 231.0 ± 3.42 13.2 ± 1.61 0.298 ± 0.04 93.22 ± 1.25 10.73 ± 0.49 6.69 ± 0.12 121.2 ± 1.20
*OAVM-2 185.1 ± 2.23 16.7 ± 1.12 0.359 ± 0.05 89.86 ± 1.35 13.11 ± 0.46 6.16 ± 0.14 118.1 ± 2.16
*OAVM-3 160.1 ± 3.09 15.3 ± 1.23 0.404 ± 0.02 91.93 ± 2.29 16.17 ± 0.43 5.89 ± 0.30 116.2 ± 1.35
*OAVM-4 245.2 ± 2.90 12.8 ± 2.13 0.378 ± 0.01 94.25 ± 2.07 13.85 ± 0.25 6.72 ± 0.13 122.2 ± 1.25
*OAVM-5 208.2 ± 2.95 14.2 ± 1.88 0.415 ± 0.01 92.96 ± 1.65 15.80 ± 0.26 6.58 ± 0.20 120.3 ± 1.34
*OAVM-6 165.2 ± 2.03 13.1 ± 2.09 0.461 ± 0.01 91.15 ± 1.49 18.04 ± 0.53 6.29 ± 0.11 118.8 ± 2.08
*IPMVM-7 224.4 ± 2.83 10.7 ± 1.80 0.366 ± 0.02 94.64 ± 3.82 9.86 ± 0.41 6.67 ± 0.08 112.1 ± 1.56
*IPMVM-8 194.3 ± 2.90 13.7 ± 1.87 0.402 ± 0.03 90.12 ± 1.62 12.10 ± 0.28 6.05 ± 0.10 113.1 ± 2.01
*IPMVM-9 161.9 ± 1.85 11.4 ± 1.59 0.453 ± 0.02 93.48 ± 2.60 16.12 ± 0.63 5.89 ± 0.11 115.2 ± 1.36
*IPMVM-10 203.2 ± 2.78 11.7 ± 2.09 0.407 ± 0.03 92.83 ± 3.91 9.53 ± 0.18 6.71 ± 0.05 105.1 ± 1.53
*IPMVM-11 178.9 ± 1.52 15.4 ± 1.60 0.383 ± 0.02 92.44 ± 1.95 12.78 ± 0.28 6.20 ± 0.18 106.7 ± 2.57
*IPMVM-12 158.1 ± 2.13 13.9 ± 2.34 0.402 ± 0.05 90.37 ± 2.40 16.14 ± 0.50 5.74 ± 0.10 109.9 ± 1.99
*IPPVM-13 241.4 ± 3.24 10.4 ± 1.08 0.339 ± 0.02 93.22 ± 1.78 10.47 ± 0.26 6.42 ± 0.03 110.9 ± 1.42
*IPPVM-14 195.1 ± 1.96 12.0 ± 1.38 0.409 ± 0.05 90.76 ± 2.89 11.21 ± 0.15 6.07 ± 0.16 112.2 ± 2.29
*IPPVM-15 152.3 ± 3.06 11.1 ± 1.21 0.435 ± 0.03 91.41 ± 1.91 15.43 ± 0.22 5.78 ± 0.13 114.8 ± 1.32
*IPPVM-16 222.2 ± 1.83 12.7 ± 1.56 0.441 ± 0.03 91.93 ± 2.29 11.92 ± 0.38 6.75 ± 0.07 105.1 ± 1.55
*IPPVM-17 185.9 ± 1.21 14.8 ± 1.18 0.427 ± 0.04 93.35 ± 2.88 13.68 ± 0.14 6.26 ± 0.12 106.9 ± 2.43
*IPPVM-18 156.6 ± 2.09 13.3 ± 1.19 0.361 ± 0.02 90.63 ± 2.92 16.37 ± 0.19 6.07 ± 0.19 109.6 ± 2.26

The sign ‘* ’ indicates values are mean ± S.D, i.e. in triplicates (n = 3).* OAVM –Voriconazole microemulsion with oleic acid. * IPMVM – Voriconazole microemulsion with isopropyl myristate. * IPPVM – Voriconazole microemulsion with isopropyl palmitate.PDI – Polydispersity index.