Table 4: Kinetic profiles of in vitro drug release from different selected microemulsions through dialysis membrane.
| Batch code |
Zero order |
First order |
Higuchi |
Koresmeyer-Peppas |
Hixon-Crowell |
| Dt = D0 + k0 t |
ln Dt = ln D0 + k1 t |
Dt = D0 + kH t1/2 |
Dt/D∞ = KKP tn |
Dt1/3 = D0 1/3 - KHC t |
| R2 |
K0 |
R2 |
K1 |
R2 |
KH |
R2 |
n* |
KKP |
R2 |
KHC |
| OAVM-2 |
0.9384 |
0.1045 |
0.9680 |
-0.0012 |
0.9937 |
3.2447 |
0.9892 |
0.4898 |
0.5257 |
0.9908 |
-0.0027 |
| IPMVM-8 |
0.9601 |
0.1070 |
0.9111 |
-0.0013 |
0.9710 |
3.3987 |
0.9588 |
0.5124 |
0.4288 |
0.9546 |
-0.0024 |
| IPMVM-11 |
0.9417 |
0.1036 |
0.9364 |
-0.00011 |
0.9749 |
3.1935 |
0.9660 |
0.4693 |
0.3870 |
0.9711 |
-0.0026 |
| IPPVM-14 |
0.9640 |
0.0991 |
0.9623 |
-0.0015 |
0.9876 |
3.2148 |
0.9862 |
0.5604 |
0.2854 |
0.9843 |
-0.0026 |
| IPPVM-15 |
0.9438 |
0.0971 |
0.9360 |
-0.0014 |
0.9819 |
3.3981 |
0.9588 |
0.5189 |
0.4329 |
0.9710 |
-0.0027 |
| IPPVM-17 |
0.9280 |
0.0947 |
0.9508 |
-0.0008 |
0.9841 |
2.8742 |
0.9801 |
0.4833 |
0.5074 |
0.9773 |
-0.0025 |
Where,
Dt is the amount of drug released at time t, D0 is the initial amount of drug released, Dt/D∞ is fraction of drug released at time t,
k0 is the zero order release constant, k1 is the first order release constant, kH is the Higuchi release constant, kHC is the Hixson-Crowell rate constant, KKP is the Koresmeyer-Peppas release constant, R2 is the regression coefficient values of drug release data calculated from various drug release kinetic models, n* is the diffusional exponent.