Table 5: In vitro transcorneal permeation profile with corneal hydration level of selected voriconazole microemulsions and VOZOLE (1% w/v) (mean ± SD, n=3).

Formulations Amount of drug permeated in
4 hrs
Permeation (%) Corneal hydration level (%)
(µg) (mg)
VOZOLE (1% w/v) 20.747 ± 0.458 0.021 ± 0.001 2.075 ± 0.046 76.433 ± 0.188
OAVM-2 52.399 ± 0.813† 0.052 ± 0.001 5.240 ± 0.081 79.270 ± 0.256
IPMVM-11 69.073 ± 0.667†† 0.069 ± 0.001 6.907 ± 0.067 77.780 ± 0.699
IPPVM-17 47.310 ± 0.637† 0.047 ±0.001 4.731 ± 0.064 77.213 ± 0.213

†Statistically significant difference at p<0.05,††Statistically significant difference at p<0.01.