| Parameters evaluated | Period | Room Temperature (25°C ± 2°C) | Refrigerator (5°± 3°C) |
|
|---|---|---|---|---|
| Appearance of gel | At the end of 3 months | No change | No change | |
| pH of gel | At the end of 3 months | 6.65 | 6.68 | |
| Spreadability | At the end of 3 months | 14.13 | 14.11 | |
| Drug content | 1st month | 98.88 ± 0.08 | 99.21 ± 0.18 | |
| 2nd month | 97.76 ± 0.22 | 98.63 ± 0.05 | ||
| 3rd month | 96.28 ± 0.08 | 98.31 ± 0.07 | ||
| In vitro drug release study (%) at the end of 7th hr | 1st month | 48.63 ± 0.12 | 49.15 ± 0.12 | |
| 2nd month | 46.40 ± 0.007 | 48.00 ± 0.007 | ||
| 3rd month | 45.19 ± 0.02 | 47.00 ± 0.044 | ||